biostudies-literatureUnknown52(2)Spinicci MA late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.European journal of immunology352-355https://www.ebi.ac.uk/biostudies/studies/S-EPMC9015404biostudies-literatureAIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection.PMC9015404Coppi MSaccardi RRossolini GMMazzoni ABotta ABorchi BBartalesi FAnnunziato FGiovacchini NBartoloni ASpinicci MPieralli FGraziani LMazzetti MColao MGTilli MfalseAIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection.A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.2022-01-01T00:00:00Z2022 Feb2025-04-04T12:45:26.749Z2024-11-09T10:37:06.689ZS-EPMC90154043482218510.1002/eji.202149574