{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Verschoor CP"],"funding":["NIA NIH HHS","National Institutes of Health"],"pagination":["753767"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9015675"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2"],"pubmed_abstract":["<h4>Background</h4>Influenza-specific cytolytic T lymphocytes (CTL) have a critical role in clearing the virus from the lungs, but are poorly stimulated by current inactivated influenza vaccines. Our previous work suggests that granzyme B (GrB) activity predicts protection against laboratory-confirmed influenza infection (LCII) in older adults. However, basal GrB (bGrB) activity increases with age and the frequency of GrB<sup>+</sup> CTL that do not co-express perforin increases following influenza infection, thereby acting as a potential contributor to immune pathology.<h4>Objectives</h4>Using data from a 4-year randomized trial of standard- versus high-dose influenza vaccination, we sought to determine whether measurements of GrB activity alone indicate a protective vs. pathologic respon"],"journal":["Frontiers in aging"],"pubmed_title":["Granzyme B: a double-edged sword in the response to influenza infection in vaccinated older adults."],"pmcid":["PMC9015675"],"funding_grant_id":["P30 AG067988","R01 AG048023"],"pubmed_authors":["Verschoor CP","Haynes L","Kuchel GA","McElhaney JE","Pawelec G","Loeb M","Andrew MK"],"additional_accession":[]},"is_claimable":false,"name":"Granzyme B: a double-edged sword in the response to influenza infection in vaccinated older adults.","description":"<h4>Background</h4>Influenza-specific cytolytic T lymphocytes (CTL) have a critical role in clearing the virus from the lungs, but are poorly stimulated by current inactivated influenza vaccines. Our previous work suggests that granzyme B (GrB) activity predicts protection against laboratory-confirmed influenza infection (LCII) in older adults. However, basal GrB (bGrB) activity increases with age and the frequency of GrB<sup>+</sup> CTL that do not co-express perforin increases following influenza infection, thereby acting as a potential contributor to immune pathology.<h4>Objectives</h4>Using data from a 4-year randomized trial of standard- versus high-dose influenza vaccination, we sought to determine whether measurements of GrB activity alone indicate a protective vs. pathologic respon","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-09T15:23:43.181Z","creation":"2024-11-07T13:45:03.605Z"},"accession":"S-EPMC9015675","cross_references":{"pubmed":["35441156"],"doi":["10.3389/fragi.2021.753767"]}}