biostudies-literatureUnknown13(4)Anagnostopoulos GLigue Contre le CancerAgence Nationale de la RechercheInstitut National Du CancerFondation LeducqFondation pour la Recherche MédicaleAcyl-coenzyme-A-binding protein (ACBP), also known as a diazepam-binding inhibitor (DBI), is a potent stimulator of appetite and lipogenesis. Bioinformatic analyses combined with systematic screens revealed that peroxisome proliferator-activated receptor gamma (PPARγ) is the transcription factor that best explains the ACBP/DBI upregulation in metabolically active organs including the liver and adipose tissue. The PPARγ agonist rosiglitazone-induced ACBP/DBI upregulation, as well as weight gain, that could be prevented by knockout of Acbp/Dbi in mice. Moreover, liver-specific knockdown of Pparg prevented the high-fat diet (HFD)-induced upregulation of circulating ACBP/DBI levels and reduced body weight gain. Conversely, knockout of Acbp/Dbi prevented the HFD-induced upregulation of PPARγ. NCell death & disease356https://www.ebi.ac.uk/biostudies/studies/S-EPMC9016078biostudies-literatureAn obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABA_A receptor.PMC9016078Carbonnier VDesdouets CLambertucci FMontegut LSandrine GBourgin MChen HKroemer GMaiuri MCAnagnostopoulos GBravo-San Pedro JMAprahamian FSica VDurand SLi SSola MSNirmalathasan NMartins IMotino OKotta KSurdez DDonne RDelattre OfalseAn obesogenic feedforward loop involving PPARγ, acyl-CoA binding protein and GABA_A receptor.Acyl-coenzyme-A-binding protein (ACBP), also known as a diazepam-binding inhibitor (DBI), is a potent stimulator of appetite and lipogenesis. Bioinformatic analyses combined with systematic screens revealed that peroxisome proliferator-activated receptor gamma (PPARγ) is the transcription factor that best explains the ACBP/DBI upregulation in metabolically active organs including the liver and adipose tissue. The PPARγ agonist rosiglitazone-induced ACBP/DBI upregulation, as well as weight gain, that could be prevented by knockout of Acbp/Dbi in mice. Moreover, liver-specific knockdown of Pparg prevented the high-fat diet (HFD)-induced upregulation of circulating ACBP/DBI levels and reduced body weight gain. Conversely, knockout of Acbp/Dbi prevented the HFD-induced upregulation of PPARγ. N2022-01-01T00:00:00Z2022 Apr2026-06-18T05:04:45.997Z2025-02-19T04:20:46.634ZS-EPMC90160783543699310.1038/s41419-022-04834-5