{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ramani-Chander A"],"funding":["FIC NIH HHS","Medical Research Council","NHLBI NIH HHS","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["e053122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9016402"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(4)"],"pubmed_abstract":["<h4>Introduction</h4>There is an urgent need to reduce the burden of non-communicable diseases (NCDs), particularly in low-and middle-income countries, where the greatest burden lies. Yet, there is little research concerning the specific issues involved in scaling up NCD interventions targeting low-resource settings. We propose to examine this gap in up to 27 collaborative projects, which were funded by the Global Alliance for Chronic Diseases (GACD) 2019 Scale Up Call, reflecting a total funding investment of approximately US$50 million. These projects represent diverse countries, contexts and adopt varied approaches and study designs to scale-up complex, evidence-based interventions to improve hypertension and diabetes outcomes. A systematic inquiry of these projects will provide necessa"],"journal":["BMJ open"],"pubmed_title":["Applying systems thinking to identify enablers and challenges to scale-up interventions for hypertension and diabetes in low-income and middle-income countries: protocol for a longitudinal mixed-methods study."],"pmcid":["PMC9016402"],"funding_grant_id":["MR/J015903/1","MR/P012590/1","16/136/77","MR/T02528X/1","MR/T024399/1","UH3 HL152381","R21 TW009982","MR/T004959/1","MR/V005847/1"],"pubmed_authors":["Wouters E","Patel A","He FJ","Postma M","Agarwal G","Klipstein-Grobusch K","Zhang P","Irazola VE","Peiris D","Sujarwoto S","Koot J","Waqa G","Lazo-Porras M","Probandari A","Tampubolon G","Nakamura K","Webster J","Owolabi MO","Shrestha A","Levitt N","Li Y","Global Alliance for Chronic Diseases Upscaling Working Group Collaborators.","Beratarrechea A","Oldenburg B","Naanyu V","Thrift AG","Birungi J","De Neve JW","Ribeiro ALP","Liu H","Gonzalez-Salazar F","Martens M","Esandi ME","Mfinanga SG","Ojji D","Sugishita T","Miranda JJ","Ramani-Chander A","Vedanthan R","Ortiz Z","Delobelle P","Sherwood S","Joshi R","Geldsetzer P","Huffman MD","Tian M","Mash RJ","Haghparast-Bidgoli H","Antonietti L","Schouw D","Marcolino MS","Siddiqi K","van Olmen J","Rawal LB","Daivadanam M","Batal M","Paredes M"],"additional_accession":[]},"is_claimable":false,"name":"Applying systems thinking to identify enablers and challenges to scale-up interventions for hypertension and diabetes in low-income and middle-income countries: protocol for a longitudinal mixed-methods study.","description":"<h4>Introduction</h4>There is an urgent need to reduce the burden of non-communicable diseases (NCDs), particularly in low-and middle-income countries, where the greatest burden lies. Yet, there is little research concerning the specific issues involved in scaling up NCD interventions targeting low-resource settings. We propose to examine this gap in up to 27 collaborative projects, which were funded by the Global Alliance for Chronic Diseases (GACD) 2019 Scale Up Call, reflecting a total funding investment of approximately US$50 million. These projects represent diverse countries, contexts and adopt varied approaches and study designs to scale-up complex, evidence-based interventions to improve hypertension and diabetes outcomes. A systematic inquiry of these projects will provide necessa","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-03-18T13:39:49.051Z","creation":"2025-02-19T01:23:22.809Z"},"accession":"S-EPMC9016402","cross_references":{"pubmed":["35437244"],"doi":["10.1136/bmjopen-2021-053122"]}}