biostudies-literatureRamani-Chander AFIC NIH HHSMedical Research CouncilNHLBI NIH HHSNational Institute for Health Research (NIHR)Wellcome Truste053122https://www.ebi.ac.uk/biostudies/studies/S-EPMC9016402biostudies-literatureUnknown12(4)<h4>Introduction</h4>There is an urgent need to reduce the burden of non-communicable diseases (NCDs), particularly in low-and middle-income countries, where the greatest burden lies. Yet, there is little research concerning the specific issues involved in scaling up NCD interventions targeting low-resource settings. We propose to examine this gap in up to 27 collaborative projects, which were funded by the Global Alliance for Chronic Diseases (GACD) 2019 Scale Up Call, reflecting a total funding investment of approximately US$50 million. These projects represent diverse countries, contexts and adopt varied approaches and study designs to scale-up complex, evidence-based interventions to improve hypertension and diabetes outcomes. A systematic inquiry of these projects will provide necessaBMJ openApplying systems thinking to identify enablers and challenges to scale-up interventions for hypertension and diabetes in low-income and middle-income countries: protocol for a longitudinal mixed-methods study.PMC9016402MR/J015903/1MR/P012590/116/136/77MR/T02528X/1MR/T024399/1UH3 HL152381R21 TW009982MR/T004959/1MR/V005847/1Wouters EPatel AHe FJPostma MAgarwal GKlipstein-Grobusch KZhang PIrazola VEPeiris DSujarwoto SKoot JWaqa GLazo-Porras MProbandari ATampubolon GNakamura KWebster JOwolabi MOShrestha ALevitt NLi YGlobal Alliance for Chronic Diseases Upscaling Working Group Collaborators.Beratarrechea AOldenburg BNaanyu VThrift AGBirungi JDe Neve JWRibeiro ALPLiu HGonzalez-Salazar FMartens MEsandi MEMfinanga SGOjji DSugishita TMiranda JJRamani-Chander AVedanthan ROrtiz ZDelobelle PSherwood SJoshi RGeldsetzer PHuffman MDTian MMash RJHaghparast-Bidgoli HAntonietti LSchouw DMarcolino MSSiddiqi Kvan Olmen JRawal LBDaivadanam MBatal MParedes MfalseApplying systems thinking to identify enablers and challenges to scale-up interventions for hypertension and diabetes in low-income and middle-income countries: protocol for a longitudinal mixed-methods study.<h4>Introduction</h4>There is an urgent need to reduce the burden of non-communicable diseases (NCDs), particularly in low-and middle-income countries, where the greatest burden lies. Yet, there is little research concerning the specific issues involved in scaling up NCD interventions targeting low-resource settings. We propose to examine this gap in up to 27 collaborative projects, which were funded by the Global Alliance for Chronic Diseases (GACD) 2019 Scale Up Call, reflecting a total funding investment of approximately US$50 million. These projects represent diverse countries, contexts and adopt varied approaches and study designs to scale-up complex, evidence-based interventions to improve hypertension and diabetes outcomes. A systematic inquiry of these projects will provide necessa2022-01-01T00:00:00Z2022 Apr2026-03-18T13:39:49.051Z2025-02-19T01:23:22.809ZS-EPMC90164023543724410.1136/bmjopen-2021-053122