{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Yang H"],"funding":["NIGMS NIH HHS"],"pubmed_abstract":["<b>Background.</b> Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histamine 2 receptor (H2R) antagonist widely used to treat gastroesophageal reflux disease , attenuates the clinical course of COVID-19. Because evidence is lacking for a direct antiviral activity of famotidine, a proposed mechanism of action is blocking the effects of histamine released by mast cells. Here we hypothesized that famotidine activates the inflammatory reflex, a brain-integrated vagus nerve mechanism which inhibits inflammation via alpha 7 nicotinic acetylcholine receptor ( α7nAChR ) signal transduction, to prevent cytokine storm. <b>Methods.</b> The potentia"],"journal":["Research square"],"pagination":["rs.3.rs-1493296"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9016653"],"repository":["biostudies-literature"],"pubmed_title":["Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm."],"pmcid":["PMC9016653"],"funding_grant_id":["R35 GM118182","R01 GM132672"],"pubmed_authors":["Yang H","Tynan A","Andersson U","Tracey KJ","Chang E","Pavlov VA","Tsaava T","Chavan SS","Brines M","George SJ","Thompson D","Silverman HA"],"additional_accession":[]},"is_claimable":false,"name":"Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm.","description":"<b>Background.</b> Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histamine 2 receptor (H2R) antagonist widely used to treat gastroesophageal reflux disease , attenuates the clinical course of COVID-19. Because evidence is lacking for a direct antiviral activity of famotidine, a proposed mechanism of action is blocking the effects of histamine released by mast cells. Here we hypothesized that famotidine activates the inflammatory reflex, a brain-integrated vagus nerve mechanism which inhibits inflammation via alpha 7 nicotinic acetylcholine receptor ( α7nAChR ) signal transduction, to prevent cytokine storm. <b>Methods.</b> The potentia","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T19:09:57.427Z","creation":"2025-02-19T01:24:02.616Z"},"accession":"S-EPMC9016653","cross_references":{"pubmed":["35441176"],"doi":["10.21203/rs.3.rs-1493296/v1"]}}