{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qiu L"],"funding":["Scientific and Technological Projects of Guangzhou","Natural Science Foundation of Guangdong Province","Guangdong Provincial People?s Hospital"],"pagination":["12030-12038"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9016885"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(14)"],"pubmed_abstract":["Aseptic loosening is the main factor that leads to the failure of orthopedic implants. Enhancing the early osteointegration of a bone implant can lower the risk of aseptic loosening. Here, a Li-doped surface was constructed on a Ti surface via plasma electrolytic oxidation (PEO) to improve osteointegration. The prepared Li-doped PEO coating showed a porous morphology and the sustained release of Li ions. <i>In vitro</i> results of rat bone marrow mesenchymal stem cell (rBMSC) culture studies suggested that the Li-doped Ti surface significantly favored cell adhesion. Moreover, it was found that the Li-doped surface enhanced alkaline phosphatase activity and extracellular matrix mineralization of rBMSCs. In addition, the surface improved the expression of osteogenesis-related genes. Furtherm"],"journal":["ACS omega"],"pubmed_title":["Li-Doped Ti Surface for the Improvement of Osteointegration."],"pmcid":["PMC9016885"],"funding_grant_id":["202002030283","201904010376","2020A1515011447","2020bq18","202102020514"],"pubmed_authors":["Peng F","Zhu Z","Zhang Y","Xie J","Zhou R","Zhang C","Li M","Qiu L"],"additional_accession":[]},"is_claimable":false,"name":"Li-Doped Ti Surface for the Improvement of Osteointegration.","description":"Aseptic loosening is the main factor that leads to the failure of orthopedic implants. Enhancing the early osteointegration of a bone implant can lower the risk of aseptic loosening. Here, a Li-doped surface was constructed on a Ti surface via plasma electrolytic oxidation (PEO) to improve osteointegration. The prepared Li-doped PEO coating showed a porous morphology and the sustained release of Li ions. <i>In vitro</i> results of rat bone marrow mesenchymal stem cell (rBMSC) culture studies suggested that the Li-doped Ti surface significantly favored cell adhesion. Moreover, it was found that the Li-doped surface enhanced alkaline phosphatase activity and extracellular matrix mineralization of rBMSCs. In addition, the surface improved the expression of osteogenesis-related genes. Furtherm","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-06-01T00:33:40.495Z","creation":"2024-11-13T05:23:07.107Z"},"accession":"S-EPMC9016885","cross_references":{"pubmed":["35449902"],"doi":["10.1021/acsomega.2c00229"]}}