biostudies-literatureQiu LScientific and Technological Projects of GuangzhouNatural Science Foundation of Guangdong ProvinceGuangdong Provincial People?s Hospital12030-12038https://www.ebi.ac.uk/biostudies/studies/S-EPMC9016885biostudies-literatureUnknown7(14)Aseptic loosening is the main factor that leads to the failure of orthopedic implants. Enhancing the early osteointegration of a bone implant can lower the risk of aseptic loosening. Here, a Li-doped surface was constructed on a Ti surface via plasma electrolytic oxidation (PEO) to improve osteointegration. The prepared Li-doped PEO coating showed a porous morphology and the sustained release of Li ions. <i>In vitro</i> results of rat bone marrow mesenchymal stem cell (rBMSC) culture studies suggested that the Li-doped Ti surface significantly favored cell adhesion. Moreover, it was found that the Li-doped surface enhanced alkaline phosphatase activity and extracellular matrix mineralization of rBMSCs. In addition, the surface improved the expression of osteogenesis-related genes. FurthermACS omegaLi-Doped Ti Surface for the Improvement of Osteointegration.PMC90168852020020302832019040103762020A15150114472020bq18202102020514Peng FZhu ZZhang YXie JZhou RZhang CLi MQiu LfalseLi-Doped Ti Surface for the Improvement of Osteointegration.Aseptic loosening is the main factor that leads to the failure of orthopedic implants. Enhancing the early osteointegration of a bone implant can lower the risk of aseptic loosening. Here, a Li-doped surface was constructed on a Ti surface via plasma electrolytic oxidation (PEO) to improve osteointegration. The prepared Li-doped PEO coating showed a porous morphology and the sustained release of Li ions. <i>In vitro</i> results of rat bone marrow mesenchymal stem cell (rBMSC) culture studies suggested that the Li-doped Ti surface significantly favored cell adhesion. Moreover, it was found that the Li-doped surface enhanced alkaline phosphatase activity and extracellular matrix mineralization of rBMSCs. In addition, the surface improved the expression of osteogenesis-related genes. Furtherm2022-01-01T00:00:00Z2022 Apr2025-06-01T00:33:40.495Z2024-11-13T05:23:07.107ZS-EPMC90168853544990210.1021/acsomega.2c00229