{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tang Y"],"funding":["the National Key Research and Development Program of China","National Science and Technology Program during the Twelfth Five-year Plan Period"],"pagination":["47"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9016943"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["<h4>Background</h4>Subclinical necrotic enteritis (SNE), a common intestinal disease of broiler caused by Clostridium perfringens, could reduce production performance of broilers by chronic intestinal damage and poor absorption of nutrients. Ellagic acid (EA) has been reported to present antioxidant and anti-inflammatory properties on human and animals in many aspects. This study was conducted to evaluate the effect and mechanism of EA in relieving SNE in broilers induced by C. perfringens.<h4>Results</h4>C. perfringens challenge decreased body weight (BW), average daily gain (ADG), jejunal villi height/crypt depth (V/C) ratio, the activity of catalase (CAT) and the mRNA expression of zonula occludens 1 (ZO-1) in jejunal mucosa of broilers. While feed conversion ratios (FCR), jejunal crypt"],"journal":["Journal of animal science and biotechnology"],"pubmed_title":["Dietary ellagic acid ameliorated Clostridium perfringens-induced subclinical necrotic enteritis in broilers via regulating inflammation and cecal microbiota."],"pmcid":["PMC9016943"],"funding_grant_id":["2017YFE0129900"],"pubmed_authors":["Li G","Ma Q","Zhu P","Zhao L","Guo Y","Zhang J","Zhang X","Wang Y","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"Dietary ellagic acid ameliorated Clostridium perfringens-induced subclinical necrotic enteritis in broilers via regulating inflammation and cecal microbiota.","description":"<h4>Background</h4>Subclinical necrotic enteritis (SNE), a common intestinal disease of broiler caused by Clostridium perfringens, could reduce production performance of broilers by chronic intestinal damage and poor absorption of nutrients. Ellagic acid (EA) has been reported to present antioxidant and anti-inflammatory properties on human and animals in many aspects. This study was conducted to evaluate the effect and mechanism of EA in relieving SNE in broilers induced by C. perfringens.<h4>Results</h4>C. perfringens challenge decreased body weight (BW), average daily gain (ADG), jejunal villi height/crypt depth (V/C) ratio, the activity of catalase (CAT) and the mRNA expression of zonula occludens 1 (ZO-1) in jejunal mucosa of broilers. While feed conversion ratios (FCR), jejunal crypt","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-25T19:05:39.949Z","creation":"2025-02-19T04:57:56.987Z"},"accession":"S-EPMC9016943","cross_references":{"pubmed":["35436978"],"doi":["10.1186/s40104-022-00694-3"]}}