{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bodhankar GA"],"funding":["UofI | University of Illinois at Urbana-Champaign","UofI | University of Illinois at Urbana-Champaign (UIUC)","NIGMS NIH HHS"],"pagination":["e0044121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9017305"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["204(4)"],"pubmed_abstract":["Bacillus subtilis employs 10 chemoreceptors to move in response to chemicals in its environment. While the sensing mechanisms have been determined for many attractants, little is known about the sensing mechanisms for repellents. In this work, we investigated phenol chemotaxis in B. subtilis. Phenol is an attractant at low, micromolar concentrations and a repellent at high, millimolar concentrations. McpA was found to be the principal chemoreceptor governing the repellent response to phenol and other related aromatic compounds. In addition, the chemoreceptors McpC and HemAT were found to govern the attractant response to phenol and related compounds. Using chemoreceptor chimeras, McpA was found to sense phenol using its signaling domain rather than its sensing domain. These observations we"],"journal":["Journal of bacteriology"],"pubmed_title":["Characterization of Opposing Responses to Phenol by Bacillus subtilis Chemoreceptors."],"pmcid":["PMC9017305"],"funding_grant_id":["R01 GM054365","R56 GM054365"],"pubmed_authors":["Foust ZL","Tohidifar P","Ordal GW","Rao CV","Bodhankar GA"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of Opposing Responses to Phenol by Bacillus subtilis Chemoreceptors.","description":"Bacillus subtilis employs 10 chemoreceptors to move in response to chemicals in its environment. While the sensing mechanisms have been determined for many attractants, little is known about the sensing mechanisms for repellents. In this work, we investigated phenol chemotaxis in B. subtilis. Phenol is an attractant at low, micromolar concentrations and a repellent at high, millimolar concentrations. McpA was found to be the principal chemoreceptor governing the repellent response to phenol and other related aromatic compounds. In addition, the chemoreceptors McpC and HemAT were found to govern the attractant response to phenol and related compounds. Using chemoreceptor chimeras, McpA was found to sense phenol using its signaling domain rather than its sensing domain. These observations we","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-07T07:33:52.694Z","creation":"2025-04-21T16:09:40.488Z"},"accession":"S-EPMC9017305","cross_references":{"pubmed":["35007157"],"doi":["10.1128/jb.00441-21","10.1128/JB.00441-21"]}}