{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Tripathi R"],"pubmed_abstract":["Glutamate acts as a critical regulator of neurotransmitter balance, recycling, synaptic function and homeostasis in the brain and glutamate transporters control glutamate levels in the brain. SLC38A10 is a member of the SLC38 family and regulates protein synthesis and cellular stress responses. Here, we uncover the role of SLC38A10 as a transceptor involved in glutamate-sensing signaling pathways that control both the glutamate homeostasis and mTOR-signaling. The culture of primary cortex cells from SLC38A10 knockout mice had increased intracellular glutamate. In addition, under nutrient starvation, KO cells had an impaired response in amino acid-dependent mTORC1 signaling. Combined studies from transcriptomics, protein arrays and metabolomics established that SLC38A10 is involved in mTOR "],"journal":["Frontiers in cell and developmental biology"],"pagination":["854397"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9017388"],"repository":["biostudies-literature"],"pubmed_title":["SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells."],"pmcid":["PMC9017388"],"pubmed_authors":["Aggarwal T","Lindberg FA","Fredriksson R","Klemm AH","Tripathi R"],"additional_accession":[]},"is_claimable":false,"name":"SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells.","description":"Glutamate acts as a critical regulator of neurotransmitter balance, recycling, synaptic function and homeostasis in the brain and glutamate transporters control glutamate levels in the brain. SLC38A10 is a member of the SLC38 family and regulates protein synthesis and cellular stress responses. Here, we uncover the role of SLC38A10 as a transceptor involved in glutamate-sensing signaling pathways that control both the glutamate homeostasis and mTOR-signaling. The culture of primary cortex cells from SLC38A10 knockout mice had increased intracellular glutamate. In addition, under nutrient starvation, KO cells had an impaired response in amino acid-dependent mTORC1 signaling. Combined studies from transcriptomics, protein arrays and metabolomics established that SLC38A10 is involved in mTOR ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T10:32:08.779Z","creation":"2024-11-09T18:54:38.056Z"},"accession":"S-EPMC9017388","cross_references":{"pubmed":["35450293"],"doi":["10.3389/fcell.2022.854397"]}}