{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Mahardika GN"],"funding":["Research, Technology and Higher Education (RISTEKDIKTI) of Indonesia"],"pubmed_abstract":["The prolonged global spread and community transmission of severe acute respiratory syndrome virus 2 (SARS-CoV-2) has led to the emergence of variants and brought questions regarding disease severity and vaccine effectiveness. We conducted simple bioinformatics on the spike gene of a representative of each variant. The data show that a number of polymorphic amino acids are located mostly on the amino-terminal side of the S1/S2 cleavage site. The Omicron variant diverges from the others, with the highest number of amino acid substitutions, including the receptor-binding site (RBS), epitopes, S1/S2 cleavage site, fusion peptide, and heptad repeat 1. The current sharp global increase in the frequency of the Omicron genome constitutes evidence of its high community transmissibility. In conclusi"],"journal":["Biochemistry research international"],"pagination":["2164749"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9017565"],"repository":["biostudies-literature"],"pubmed_title":["Annotating Spike Protein Polymorphic Amino Acids of Variants of SARS-CoV-2, Including Omicron."],"pmcid":["PMC9017565"],"pubmed_authors":["Mahardika BK","Mahendra NB","Mahardika GN","Suardana IBK","Pharmawati M"],"additional_accession":[]},"is_claimable":false,"name":"Annotating Spike Protein Polymorphic Amino Acids of Variants of SARS-CoV-2, Including Omicron.","description":"The prolonged global spread and community transmission of severe acute respiratory syndrome virus 2 (SARS-CoV-2) has led to the emergence of variants and brought questions regarding disease severity and vaccine effectiveness. We conducted simple bioinformatics on the spike gene of a representative of each variant. The data show that a number of polymorphic amino acids are located mostly on the amino-terminal side of the S1/S2 cleavage site. The Omicron variant diverges from the others, with the highest number of amino acid substitutions, including the receptor-binding site (RBS), epitopes, S1/S2 cleavage site, fusion peptide, and heptad repeat 1. The current sharp global increase in the frequency of the Omicron genome constitutes evidence of its high community transmissibility. In conclusi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T09:40:01.561Z","creation":"2025-02-19T03:18:26.684Z"},"accession":"S-EPMC9017565","cross_references":{"pubmed":["35450296"],"doi":["10.1155/2022/2164749"]}}