{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song J"],"funding":["National Natural Science Foundation of China"],"pagination":["e614"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9017637"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(5)"],"pubmed_abstract":["<h4>Introduction</h4>This study aimed to explore the association between the IRAK4 polymorphism rs4251545 and the severity of enterovirus 71 (EV71) infection in Chinese children.<h4>Methods</h4>We analyzed the IRAK4 polymorphism rs4251545 in 617 EV71-infected patients and 410 controls using the improved multiplex ligation detection reaction. IRAK4 mRNA expression was tested by qRT-PCR. Serum concentrations of IL-6 and NF-κB were detected using ELISA.<h4>Results</h4>The frequencies of the GA + AA genotype and A allele in the mild EV71 infection group and in the severe EV71 infection group were significantly higher than those in the normal control group. The frequency of the GA + AA genotype and A allele in severely infected EV71 patients was markedly higher than that in mildly infected EV71"],"journal":["Immunity, inflammation and disease"],"pubmed_title":["Association of the IRAK4 rs4251545 genetic polymorphism with severity of enterovirus-71 infection in Chinese children."],"pmcid":["PMC9017637"],"funding_grant_id":["81871246"],"pubmed_authors":["Pan X","Liu Y","Fan F","Guo Y","Chen Z","Yi L","Li F","Liu P","Yang C","Song J","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"Association of the IRAK4 rs4251545 genetic polymorphism with severity of enterovirus-71 infection in Chinese children.","description":"<h4>Introduction</h4>This study aimed to explore the association between the IRAK4 polymorphism rs4251545 and the severity of enterovirus 71 (EV71) infection in Chinese children.<h4>Methods</h4>We analyzed the IRAK4 polymorphism rs4251545 in 617 EV71-infected patients and 410 controls using the improved multiplex ligation detection reaction. IRAK4 mRNA expression was tested by qRT-PCR. Serum concentrations of IL-6 and NF-κB were detected using ELISA.<h4>Results</h4>The frequencies of the GA + AA genotype and A allele in the mild EV71 infection group and in the severe EV71 infection group were significantly higher than those in the normal control group. The frequency of the GA + AA genotype and A allele in severely infected EV71 patients was markedly higher than that in mildly infected EV71","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-20T00:18:04.912Z","creation":"2025-02-19T01:53:53.583Z"},"accession":"S-EPMC9017637","cross_references":{"pubmed":["35478439"],"doi":["10.1002/iid3.614"]}}