biostudies-literatureUnknown19(4)Lambert AMNIHR Birmingham Biomedical Research CentreNational Institute for Health Research (NIHR)<h4>Background</h4>Severe mental illness (SMI; schizophrenia, bipolar disorders (BDs), and other nonorganic psychoses) is associated with increased risk of cardiovascular disease (CVD) and CVD-related mortality. To date, no systematic review has investigated changes in population level CVD-related mortality over calendar time. It is unclear if this relationship has changed over time in higher-income countries with changing treatments.<h4>Methods and findings</h4>To address this gap, a systematic review was conducted, to assess the association between SMI and CVD including temporal change. Seven databases were searched (last: November 30, 2021) for cohort or case-control studies lasting ≥1 year, comparing frequency of CVD mortality or incidence in high-income countries between people with vPLoS medicinee1003960https://www.ebi.ac.uk/biostudies/studies/S-EPMC9017899biostudies-literatureTemporal trends in associations between severe mental illness and risk of cardiovascular disease: A systematic review and meta-analysis.PMC9017899Ryan RPearce EAvsar TSPrice MJOdland MLAhmed KSolmi MLee AParretti HMMatthewman GCorrell CUTyldesley-Marshall NRiley MMarshall TLambert AMfalseTemporal trends in associations between severe mental illness and risk of cardiovascular disease: A systematic review and meta-analysis.<h4>Background</h4>Severe mental illness (SMI; schizophrenia, bipolar disorders (BDs), and other nonorganic psychoses) is associated with increased risk of cardiovascular disease (CVD) and CVD-related mortality. To date, no systematic review has investigated changes in population level CVD-related mortality over calendar time. It is unclear if this relationship has changed over time in higher-income countries with changing treatments.<h4>Methods and findings</h4>To address this gap, a systematic review was conducted, to assess the association between SMI and CVD including temporal change. Seven databases were searched (last: November 30, 2021) for cohort or case-control studies lasting ≥1 year, comparing frequency of CVD mortality or incidence in high-income countries between people with v2022-01-01T00:00:00Z2022 Apr2025-04-19T17:37:14.827Z2025-04-19T17:37:14.827ZS-EPMC90178993543924310.1371/journal.pmed.1003960