{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee SB"],"funding":["U.S. Department of Health &amp; Human Services | NIH | National Cancer Institute","NCI NIH HHS","National Research Foundation of Korea"],"pagination":["2089"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9018835"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Tissue-specific transcriptional activity is silenced in mitotic cells but it remains unclear whether the mitotic regulatory machinery interacts with tissue-specific transcriptional programs. We show that such cross-talk involves the controlled interaction between core subunits of the anaphase-promoting complex (APC) and the ID2 substrate. The N-terminus of ID2 is independently and structurally compatible with a pocket composed of core APC/C subunits that may optimally orient ID2 onto the APC<sup>CDH1</sup> complex. Phosphorylation of serine-5 by CDK1 prevented the association of ID2 with core APC, impaired ubiquitylation and stabilized ID2 protein at the mitosis-G1 transition leading to inhibition of basic Helix-Loop-Helix (bHLH)-mediated transcription. The serine-5 phospho-mimetic mutant "],"journal":["Nature communications"],"pubmed_title":["Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription."],"pmcid":["PMC9018835"],"funding_grant_id":["NRF-2020R1C1C1014281","R01CA190891","NRF-2021R1A5A8029876","NRF-2020R1C1C1004015","R01CA101644","R01CA179044","NRF-2021R1A5A2031612","R01 CA239721","R01 CA101644","R01 CA179044","R01CA131126","R01 CA190891","R01CA178546","R01 CA178546","U54CA193313","R01 CA131126","U54 CA193313"],"pubmed_authors":["Garofano L","Gan Q","Cardozo T","Lasorella A","Ko A","Iavarone A","Sommer D","Kim K","D'Angelo F","Lee SB","Frangaj B"],"additional_accession":[]},"is_claimable":false,"name":"Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription.","description":"Tissue-specific transcriptional activity is silenced in mitotic cells but it remains unclear whether the mitotic regulatory machinery interacts with tissue-specific transcriptional programs. We show that such cross-talk involves the controlled interaction between core subunits of the anaphase-promoting complex (APC) and the ID2 substrate. The N-terminus of ID2 is independently and structurally compatible with a pocket composed of core APC/C subunits that may optimally orient ID2 onto the APC<sup>CDH1</sup> complex. Phosphorylation of serine-5 by CDK1 prevented the association of ID2 with core APC, impaired ubiquitylation and stabilized ID2 protein at the mitosis-G1 transition leading to inhibition of basic Helix-Loop-Helix (bHLH)-mediated transcription. The serine-5 phospho-mimetic mutant ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-31T12:58:16.516Z","creation":"2025-04-06T21:48:39.056Z"},"accession":"S-EPMC9018835","cross_references":{"pubmed":["35440621"],"doi":["10.1038/s41467-022-29502-2"]}}