{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li J"],"funding":["Ministry of Science and Technology of the People's Republic of China","National Natural Science Foundation of China"],"pagination":["2143"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9018847"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Boron neutron capture therapy (BNCT) is an attractive approach to treat invasive malignant tumours due to binary heavy-particle irradiation, but its clinical applications have been hindered by boron delivery agents with low in vivo stability, poor biocompatibility, and limited application of combinational modalities. Here, we report boronsome, a carboranyl-phosphatidylcholine based liposome for combinational BNCT and chemotherapy. Theoretical simulations and experimental approaches illustrate high stability of boronsome. Then positron emission tomography (PET) imaging with Cu-64 labelled boronsome reveals high-specific tumour accumulation and long retention with a clear irradiation background. In particular, we show the suppression of tumour growth treated with boronsome with neutron irrad"],"journal":["Nature communications"],"pubmed_title":["Boron encapsulated in a liposome can be used for combinational neutron capture therapy."],"pmcid":["PMC9018847"],"funding_grant_id":["2017YFA0506300","U1867209"],"pubmed_authors":["Liu Z","Li J","Guo Z","Sun Q","Zhang Z","Lu C","Xiao H","Duan D","Liu T"],"additional_accession":[]},"is_claimable":false,"name":"Boron encapsulated in a liposome can be used for combinational neutron capture therapy.","description":"Boron neutron capture therapy (BNCT) is an attractive approach to treat invasive malignant tumours due to binary heavy-particle irradiation, but its clinical applications have been hindered by boron delivery agents with low in vivo stability, poor biocompatibility, and limited application of combinational modalities. Here, we report boronsome, a carboranyl-phosphatidylcholine based liposome for combinational BNCT and chemotherapy. Theoretical simulations and experimental approaches illustrate high stability of boronsome. Then positron emission tomography (PET) imaging with Cu-64 labelled boronsome reveals high-specific tumour accumulation and long retention with a clear irradiation background. In particular, we show the suppression of tumour growth treated with boronsome with neutron irrad","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-22T07:51:37.786Z","creation":"2024-11-21T07:08:34.477Z"},"accession":"S-EPMC9018847","cross_references":{"pubmed":["35440126"],"doi":["10.1038/s41467-022-29780-w"]}}