biostudies-literatureLi JMinistry of Science and Technology of the People's Republic of ChinaNational Natural Science Foundation of China2143https://www.ebi.ac.uk/biostudies/studies/S-EPMC9018847biostudies-literatureUnknown13(1)Boron neutron capture therapy (BNCT) is an attractive approach to treat invasive malignant tumours due to binary heavy-particle irradiation, but its clinical applications have been hindered by boron delivery agents with low in vivo stability, poor biocompatibility, and limited application of combinational modalities. Here, we report boronsome, a carboranyl-phosphatidylcholine based liposome for combinational BNCT and chemotherapy. Theoretical simulations and experimental approaches illustrate high stability of boronsome. Then positron emission tomography (PET) imaging with Cu-64 labelled boronsome reveals high-specific tumour accumulation and long retention with a clear irradiation background. In particular, we show the suppression of tumour growth treated with boronsome with neutron irradNature communicationsBoron encapsulated in a liposome can be used for combinational neutron capture therapy.PMC90188472017YFA0506300U1867209Liu ZLi JGuo ZSun QZhang ZLu CXiao HDuan DLiu TfalseBoron encapsulated in a liposome can be used for combinational neutron capture therapy.Boron neutron capture therapy (BNCT) is an attractive approach to treat invasive malignant tumours due to binary heavy-particle irradiation, but its clinical applications have been hindered by boron delivery agents with low in vivo stability, poor biocompatibility, and limited application of combinational modalities. Here, we report boronsome, a carboranyl-phosphatidylcholine based liposome for combinational BNCT and chemotherapy. Theoretical simulations and experimental approaches illustrate high stability of boronsome. Then positron emission tomography (PET) imaging with Cu-64 labelled boronsome reveals high-specific tumour accumulation and long retention with a clear irradiation background. In particular, we show the suppression of tumour growth treated with boronsome with neutron irrad2022-01-01T00:00:00Z2022 Apr2025-04-22T07:51:37.786Z2024-11-21T07:08:34.477ZS-EPMC90188473544012610.1038/s41467-022-29780-w