{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Clarkson CS"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS","Medical Research Council","Wellcome Trust"],"pagination":["5303-5317"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9019111"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(21)"],"pubmed_abstract":["Resistance to pyrethroid insecticides is a major concern for malaria vector control. Pyrethroids target the voltage-gated sodium channel (VGSC), an essential component of the mosquito nervous system. Substitutions in the amino acid sequence can induce a resistance phenotype. We use whole-genome sequence data from phase 2 of the Anopheles gambiae 1000 Genomes Project (Ag1000G) to provide a comprehensive account of genetic variation in the Vgsc gene across 13 African countries. In addition to known resistance alleles, we describe 20 other non-synonymous nucleotide substitutions at appreciable population frequency and map these variants onto a protein model to investigate the likelihood of pyrethroid resistance phenotypes. Thirteen of these novel alleles were found to occur almost exclusively"],"journal":["Molecular ecology"],"pubmed_title":["The genetic architecture of target-site resistance to pyrethroid insecticides in the African malaria vectors Anopheles gambiae and Anopheles coluzzii."],"pmcid":["PMC9019111"],"funding_grant_id":["R01AI116811","MR/M006212/1","090770/Z/09/Z","R01 AI116811","MR/P02520X/1","G0600718B","098051","090532/Z/09/Z","204911/Z/16/Z"],"pubmed_authors":["Harding NJ","Miles A","Kwiatkowski D","Donnelly MJ","Anopheles gambiae 1000 Genomes Consortium","O'Reilly AO","Weetman D","Clarkson CS"],"additional_accession":[]},"is_claimable":false,"name":"The genetic architecture of target-site resistance to pyrethroid insecticides in the African malaria vectors Anopheles gambiae and Anopheles coluzzii.","description":"Resistance to pyrethroid insecticides is a major concern for malaria vector control. Pyrethroids target the voltage-gated sodium channel (VGSC), an essential component of the mosquito nervous system. Substitutions in the amino acid sequence can induce a resistance phenotype. We use whole-genome sequence data from phase 2 of the Anopheles gambiae 1000 Genomes Project (Ag1000G) to provide a comprehensive account of genetic variation in the Vgsc gene across 13 African countries. In addition to known resistance alleles, we describe 20 other non-synonymous nucleotide substitutions at appreciable population frequency and map these variants onto a protein model to investigate the likelihood of pyrethroid resistance phenotypes. Thirteen of these novel alleles were found to occur almost exclusively","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-09T23:44:14.569Z","creation":"2025-04-04T22:14:53.226Z"},"accession":"S-EPMC9019111","cross_references":{"pubmed":["33590926"],"doi":["10.1111/mec.15845"]}}