{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["96"],"submitter":["Lin Y"],"pubmed_abstract":["<h4>Background</h4>Spinal surgery is associated with severe pain within the first few days after surgery. Opioids are commonly used to control postoperative pain, but these can lead to postoperative nausea and vomiting (PONV). Therefore, use of more effective and better-tolerated agents would be beneficial for these patients. Serotonin receptor antagonists, such as ramosetron, have been used to reduce PONV in patients receiving anesthesia.<h4>Objective</h4>We conducted a meta-analysis of published randomized controlled trials (RCTs) to compare the efficacy and tolerance of ramosetron to prevent PONV after spinal surgery.<h4>Methods</h4>Medline, Embase, Cochrane Library, and Science Citation Index databases were systematically searched for relevant RCT articles published between January 197"],"journal":["Current therapeutic research, clinical and experimental"],"pagination":["100666"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9019236"],"repository":["biostudies-literature"],"pubmed_title":["Effects of Ramosetron on Nausea and Vomiting Following Spinal Surgery: A Meta-Analysis."],"pmcid":["PMC9019236"],"pubmed_authors":["Zhicheng Z","Xiaobin C","Lin Y","Tiansheng S","Fang L"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Ramosetron on Nausea and Vomiting Following Spinal Surgery: A Meta-Analysis.","description":"<h4>Background</h4>Spinal surgery is associated with severe pain within the first few days after surgery. Opioids are commonly used to control postoperative pain, but these can lead to postoperative nausea and vomiting (PONV). Therefore, use of more effective and better-tolerated agents would be beneficial for these patients. Serotonin receptor antagonists, such as ramosetron, have been used to reduce PONV in patients receiving anesthesia.<h4>Objective</h4>We conducted a meta-analysis of published randomized controlled trials (RCTs) to compare the efficacy and tolerance of ramosetron to prevent PONV after spinal surgery.<h4>Methods</h4>Medline, Embase, Cochrane Library, and Science Citation Index databases were systematically searched for relevant RCT articles published between January 197","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-25T18:00:20.568Z","creation":"2025-04-25T18:00:20.568Z"},"accession":"S-EPMC9019236","cross_references":{"pubmed":["35464291"],"doi":["10.1016/j.curtheres.2022.100666"]}}