biostudies-literatureUnknown12Belltall A<h4>Background</h4>There is growing interest in the possible effect of perioperative anesthetic management on the growth and spread of cancer. The impact of perioperative use of opioids on cancer recurrence remains controversial and an assessment cannot yet be established based on current publications. This study aimed to assess the differential expression of opioid receptors between healthy and tumor tissues in patients with stage II and III colorectal cancer undergoing elective surgery by immunohistochemistry (IHC).<h4>Methods</h4>Propensity-score matched case-control study nested in a retrospective cohort of patients with stage II or III colorectal. The primary endpoint was the difference in µ-opioid receptor (MOR) expression measured by IHC between tumor and healthy tissue in subject wFrontiers in oncology801714https://www.ebi.ac.uk/biostudies/studies/S-EPMC9019344biostudies-literatureOpioid Receptor Expression in Colorectal Cancer: A Nested Matched Case-Control Study.PMC9019344Argente-Navarro MPDiaz-Cambronero OEroles PBelltall AGarrido-Cano IGiner FMari AMCata JPMazzinari GfalseOpioid Receptor Expression in Colorectal Cancer: A Nested Matched Case-Control Study.<h4>Background</h4>There is growing interest in the possible effect of perioperative anesthetic management on the growth and spread of cancer. The impact of perioperative use of opioids on cancer recurrence remains controversial and an assessment cannot yet be established based on current publications. This study aimed to assess the differential expression of opioid receptors between healthy and tumor tissues in patients with stage II and III colorectal cancer undergoing elective surgery by immunohistochemistry (IHC).<h4>Methods</h4>Propensity-score matched case-control study nested in a retrospective cohort of patients with stage II or III colorectal. The primary endpoint was the difference in µ-opioid receptor (MOR) expression measured by IHC between tumor and healthy tissue in subject w2022-01-01T00:00:00Z20222025-04-04T19:31:45.756Z2025-02-19T02:57:36.519ZS-EPMC90193443546333110.3389/fonc.2022.801714