biostudies-literatureUnknown5(4)Nickols NG<h4>Importance</h4>SARS-CoV-2 entry requires the TMPRSS2 cell surface protease. Antiandrogen therapies reduce expression of TMPRSS2.<h4>Objective</h4>To determine if temporary androgen suppression induced by degarelix improves clinical outcomes of inpatients hospitalized with COVID-19.<h4>Design, setting, and participants</h4>The Hormonal Intervention for the Treatment in Veterans With COVID-19 Requiring Hospitalization (HITCH) phase 2, placebo-controlled, double-blind, randomized clinical trial compared efficacy of degarelix plus standard care vs placebo plus standard care on clinical outcomes in men hospitalized with COVID-19 but not requiring invasive mechanical ventilation. Inpatients were enrolled at 14 Department of Veterans Affairs hospitals from July 22, 2020, to April 8, 2021. DatJAMA network opene227852https://www.ebi.ac.uk/biostudies/studies/S-EPMC9020208biostudies-literatureEffect of Androgen Suppression on Clinical Outcomes in Hospitalized Men With COVID-19: The HITCH Randomized Clinical Trial.PMC9020208Wong YNBedimo RJAguayo SMGoetz MBSoo Hoo GMirsaeidi MSVillareal RCMuthiah MPClise CEHuggins JTBelligund PMMi ZSchoen MWAdorno Febles VRettig MBBiswas KOrshansky GGhayouri LAl-Ajam MGeelhoed MTsai SMaraka SMontgomery RBRobinson KWDeMatt ELevin ERBecker DJAmbrogini EGraber CJTran SNickols NGBhattacharya DMakarov DVNorman LEfalseEffect of Androgen Suppression on Clinical Outcomes in Hospitalized Men With COVID-19: The HITCH Randomized Clinical Trial.<h4>Importance</h4>SARS-CoV-2 entry requires the TMPRSS2 cell surface protease. Antiandrogen therapies reduce expression of TMPRSS2.<h4>Objective</h4>To determine if temporary androgen suppression induced by degarelix improves clinical outcomes of inpatients hospitalized with COVID-19.<h4>Design, setting, and participants</h4>The Hormonal Intervention for the Treatment in Veterans With COVID-19 Requiring Hospitalization (HITCH) phase 2, placebo-controlled, double-blind, randomized clinical trial compared efficacy of degarelix plus standard care vs placebo plus standard care on clinical outcomes in men hospitalized with COVID-19 but not requiring invasive mechanical ventilation. Inpatients were enrolled at 14 Department of Veterans Affairs hospitals from July 22, 2020, to April 8, 2021. Dat2022-01-01T00:00:00Z2022 Apr2026-05-31T01:07:34.833Z2025-04-04T11:31:36.789ZS-EPMC90202083543875410.1001/jamanetworkopen.2022.7852