{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kelshiker MA"],"funding":["British Heart Foundation","M.J.S.-S.","Medical Research Council","National Institute for Health Research (NIHR)","M.F.","National Insitute for Health Research Academy","Wellcome Trust","D.F.","R.P.","C.A.R."],"pagination":["1582-1593"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9020988"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(16)"],"pubmed_abstract":["<h4>Aims</h4>This meta-analysis aims to quantify the association of reduced coronary flow with all-cause mortality and major adverse cardiovascular events (MACE) across a broad range of patient groups and pathologies.<h4>Methods and results</h4>We systematically identified all studies between 1 January 2000 and 1 August 2020, where coronary flow was measured and clinical outcomes were reported. The endpoints were all-cause mortality and MACE. Estimates of effect were calculated from published hazard ratios (HRs) using a random-effects model. Seventy-nine studies with a total of 59 740 subjects were included. Abnormal coronary flow reserve (CFR) was associated with a higher incidence of all-cause mortality [HR: 3.78, 95% confidence interval (CI): 2.39-5.97] and a higher incidence of MACE (H"],"journal":["European heart journal"],"pubmed_title":["Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis."],"pmcid":["PMC9020988"],"funding_grant_id":["FS 04/079","212183/Z/18/Z","FS/11/46/28861","214567/Z/18/Z","MR/S021108/1","CL-2020-21-004","NIHR300166","MR/V001620/1","FS/14/25/30676","FS/14/27/30752","CL-2018-21-001","PG/15/7/31235"],"pubmed_authors":["Al-Lamee R","Shun-Shin MJ","Howard JP","Petraco R","Seligman H","Nowbar AN","Rajkumar CA","Ahmad Y","Rahman H","Foley M","Kelshiker MA","Sen S"],"additional_accession":[]},"is_claimable":false,"name":"Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.","description":"<h4>Aims</h4>This meta-analysis aims to quantify the association of reduced coronary flow with all-cause mortality and major adverse cardiovascular events (MACE) across a broad range of patient groups and pathologies.<h4>Methods and results</h4>We systematically identified all studies between 1 January 2000 and 1 August 2020, where coronary flow was measured and clinical outcomes were reported. The endpoints were all-cause mortality and MACE. Estimates of effect were calculated from published hazard ratios (HRs) using a random-effects model. Seventy-nine studies with a total of 59 740 subjects were included. Abnormal coronary flow reserve (CFR) was associated with a higher incidence of all-cause mortality [HR: 3.78, 95% confidence interval (CI): 2.39-5.97] and a higher incidence of MACE (H","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-06-01T03:50:01.378Z","creation":"2024-11-19T15:00:57.35Z"},"accession":"S-EPMC9020988","cross_references":{"pubmed":["34849697"],"doi":["10.1093/eurheartj/ehab775"]}}