{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Hu M"],"pubmed_abstract":["This study investigated the protective properties and mechanisms of D-mannose against hepatic steatosis in experimental alcoholic liver disease (ALD). Drinking-water supplementation of D-mannose significantly attenuated hepatic steatosis in a standard mouse ALD model established by chronic-binge ethanol feeding, especially hepatocyte lipid deposition. This function of D-mannose on lipid accumulation in hepatocytes was also confirmed using ethanol-treated primary mouse hepatocytes (PMHs) with a D-mannose supplement. Meanwhile, D-mannose regulated lipid metabolism by rescuing ethanol-mediated reduction of fatty acid oxidation genes (PPARα, ACOX1, CPT1) and elevation of lipogenic genes (SREBP1c, ACC1, FASN). PI3K/Akt/mTOR signaling pathway was involved in this effect of D-mannose on lipid met"],"journal":["Frontiers in immunology"],"pagination":["877650"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9021718"],"repository":["biostudies-literature"],"pubmed_title":["D-Mannose Regulates Hepatocyte Lipid Metabolism <i>via</i> PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease."],"pmcid":["PMC9021718"],"pubmed_authors":["Chang B","Luo J","Lu X","Chen Z","Zhang Y","Hu M","Dong L","Chen Y","Deng F","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"D-Mannose Regulates Hepatocyte Lipid Metabolism <i>via</i> PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease.","description":"This study investigated the protective properties and mechanisms of D-mannose against hepatic steatosis in experimental alcoholic liver disease (ALD). Drinking-water supplementation of D-mannose significantly attenuated hepatic steatosis in a standard mouse ALD model established by chronic-binge ethanol feeding, especially hepatocyte lipid deposition. This function of D-mannose on lipid accumulation in hepatocytes was also confirmed using ethanol-treated primary mouse hepatocytes (PMHs) with a D-mannose supplement. Meanwhile, D-mannose regulated lipid metabolism by rescuing ethanol-mediated reduction of fatty acid oxidation genes (PPARα, ACOX1, CPT1) and elevation of lipogenic genes (SREBP1c, ACC1, FASN). PI3K/Akt/mTOR signaling pathway was involved in this effect of D-mannose on lipid met","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T12:56:12.929Z","creation":"2025-04-04T12:56:12.929Z"},"accession":"S-EPMC9021718","cross_references":{"pubmed":["35464439"],"doi":["10.3389/fimmu.2022.877650"]}}