biostudies-literatureUnknown12Chen H<h4>Background</h4>Early screening of clinically significant prostate cancer (csPCa) may offer opportunities in revolutionizing the survival benefits of this lethal disease. We sought to introduce a modified prostate health index density (mPHI) model using imaging indicators and to compare its diagnostic performance for early detection of occult onset csPCa within the prostate-specific antigen (PSA) gray zone with that of PHI and PHID.<h4>Methods and participation</h4>Between August 2020 and January 2022, a training cohort of 278 patients (total PSA 4.0-10.0 ng/ml) who were scheduled for a prostate biopsy were prospectively recruited. PHI and PHID were compared with mPHI (LDTRD×APD×TPV×PHI) for the diagnosis performance in identifying csPCa. Pathology outcomes from systematic prostate biopFrontiers in oncology864111https://www.ebi.ac.uk/biostudies/studies/S-EPMC9021722biostudies-literatureModified Prostate Health Index Density Significantly Improves Clinically Significant Prostate Cancer (csPCa) Detection.PMC9021722Qian YShi BGu ZChen HQu FDing JWu YZhou JYu YfalseModified Prostate Health Index Density Significantly Improves Clinically Significant Prostate Cancer (csPCa) Detection.<h4>Background</h4>Early screening of clinically significant prostate cancer (csPCa) may offer opportunities in revolutionizing the survival benefits of this lethal disease. We sought to introduce a modified prostate health index density (mPHI) model using imaging indicators and to compare its diagnostic performance for early detection of occult onset csPCa within the prostate-specific antigen (PSA) gray zone with that of PHI and PHID.<h4>Methods and participation</h4>Between August 2020 and January 2022, a training cohort of 278 patients (total PSA 4.0-10.0 ng/ml) who were scheduled for a prostate biopsy were prospectively recruited. PHI and PHID were compared with mPHI (LDTRD×APD×TPV×PHI) for the diagnosis performance in identifying csPCa. Pathology outcomes from systematic prostate biop2022-01-01T00:00:00Z20222025-04-20T00:17:59.476Z2025-02-19T01:53:47.969ZS-EPMC90217223546334410.3389/fonc.2022.864111