{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["39(4)"],"submitter":["Di D"],"funding":["Swiss National Science Foundation"],"pubmed_abstract":["In a recent article, Immel et al. (Immel A, Key FM, Szolek A, Barquera R, Robinson MK, Harrison GF, Palmer WH, Spyrou MA, Susat J, Krause-Kyora B, et al. 2021. Analysis of genomic DNA from medieval plague victims suggests long-term effect of Yersinia pestis on human immunity genes. Mol Biol Evol. 38:4059-4076) extracted DNA from 36 individuals dead from plague in Ellwangen, Southern Germany, during the 16th century. By comparing their human leukocyte antigen (HLA) genotypes with those of 50 present-day Ellwangen inhabitants, the authors reported a significant decrease of HLA-B*51:01 and HLA-C*06:02 and a significant increase of HLA-DRB1*13:01/13:02 frequencies from ancient to modern populations. After comparing these frequencies with a larger sample of 8,862 modern Germans and performing s"],"journal":["Molecular biology and evolution"],"pagination":["msac073"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9021733"],"repository":["biostudies-literature"],"pubmed_title":["Challenging Ancient DNA Results About Putative HLA Protection or Susceptibility to Yersinia pestis."],"pmcid":["PMC9021733"],"pubmed_authors":["Nunes JM","Currat M","Di D","Simon Thomas J","Sanchez-Mazas A"],"additional_accession":[]},"is_claimable":false,"name":"Challenging Ancient DNA Results About Putative HLA Protection or Susceptibility to Yersinia pestis.","description":"In a recent article, Immel et al. (Immel A, Key FM, Szolek A, Barquera R, Robinson MK, Harrison GF, Palmer WH, Spyrou MA, Susat J, Krause-Kyora B, et al. 2021. Analysis of genomic DNA from medieval plague victims suggests long-term effect of Yersinia pestis on human immunity genes. Mol Biol Evol. 38:4059-4076) extracted DNA from 36 individuals dead from plague in Ellwangen, Southern Germany, during the 16th century. By comparing their human leukocyte antigen (HLA) genotypes with those of 50 present-day Ellwangen inhabitants, the authors reported a significant decrease of HLA-B*51:01 and HLA-C*06:02 and a significant increase of HLA-DRB1*13:01/13:02 frequencies from ancient to modern populations. After comparing these frequencies with a larger sample of 8,862 modern Germans and performing s","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-19T21:47:27.273Z","creation":"2025-04-19T21:47:27.273Z"},"accession":"S-EPMC9021733","cross_references":{"pubmed":["35383854"],"doi":["10.1093/molbev/msac073"]}}