{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Rempe J"],"pubmed_abstract":["<h4>Background</h4>Physical activity (PA) increases bone mass, especially in late prepuberty and early puberty, but it remains unclear if and how PA affects both bone formation and bone resorption.<h4>Materials and methods</h4>We included 191 boys and 158 girls aged 7.7 ± 0.6 (mean ± SD) in a population-based PA intervention study. The intervention group (123 boys and 94 girls) received daily physical education (PE) in school (40 min/day; 200 min/week) from study start and during the nine compulsory school years in Sweden. The controls (68 boys and 64 girls) received the national standard of 1-2 classes PE/week (60 min/week). During the intervention, blood samples were collected at ages 9.9 ± 0.6 (<i>n</i> = 172; all in Tanner stages 1-2) and 14.8 ± 0.8 (<i>n</i> = 146; all in Tanner stages 3-5) and after termination of the intervention at age 18.8 ± 0.3 (<i>n</i> = 93; all in Tanner stage 5) and 23.5 ± 0.7 (<i>n</i> = 152). In serum, we analyzed bone formation markers [bone-specific alkaline phosphatase (bALP), osteocalcin (OC), and N-terminal propeptide of collagen type 1 (PINP)] and bone resorption markers [C-terminal telopeptide cross links (CTX) and tartrate-resistant acid phosphatase (TRAcP 5b)]. Linear regression was used to compare age and sex-adjusted mean differences between intervention children and controls in these markers.<h4>Results</h4>Two years after the intervention was initiated (at Tanner stages 1-2), we found higher serum levels of bALP and OC, and lower serum levels of TRAcP 5b in the intervention compared with the control group. The mean difference (95% CI) was for bALP: 13.7 (2.1, 25.3) μg/L, OC: 9.1 (0.1, 18.1) μg/L, and TRAcP 5b: -2.3 (-3.9, -0.7) U/L. At Tanner stages 3-5 and after the intervention was terminated, bone turnover markers were similar in the intervention and the control children.<h4>Conclusion</h4>Daily school PA in the late prepubertal and early pubertal periods is associated with higher bone formation and lower bone resorption than school PA 1-2 times/week. In late pubertal and postpubertal periods, bone formation and resorption were similar. Termination of the intervention is not associated with adverse bone turnover, indicating that PA-induced bone mass benefits gained during growth may remain in adulthood."],"journal":["Frontiers in physiology"],"pagination":["828508"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9021887"],"repository":["biostudies-literature"],"pubmed_title":["Physical Activity in Late Prepuberty and Early Puberty Is Associated With High Bone Formation and Low Bone Resorption."],"pmcid":["PMC9021887"],"pubmed_authors":["Rempe J","Jehpsson L","Karlsson MK","Rosengren BE","Dencker M","Sward P"],"additional_accession":[]},"is_claimable":false,"name":"Physical Activity in Late Prepuberty and Early Puberty Is Associated With High Bone Formation and Low Bone Resorption.","description":"<h4>Background</h4>Physical activity (PA) increases bone mass, especially in late prepuberty and early puberty, but it remains unclear if and how PA affects both bone formation and bone resorption.<h4>Materials and methods</h4>We included 191 boys and 158 girls aged 7.7 ± 0.6 (mean ± SD) in a population-based PA intervention study. The intervention group (123 boys and 94 girls) received daily physical education (PE) in school (40 min/day; 200 min/week) from study start and during the nine compulsory school years in Sweden. The controls (68 boys and 64 girls) received the national standard of 1-2 classes PE/week (60 min/week). During the intervention, blood samples were collected at ages 9.9 ± 0.6 (<i>n</i> = 172; all in Tanner stages 1-2) and 14.8 ± 0.8 (<i>n</i> = 146; all in Tanner stages 3-5) and after termination of the intervention at age 18.8 ± 0.3 (<i>n</i> = 93; all in Tanner stage 5) and 23.5 ± 0.7 (<i>n</i> = 152). In serum, we analyzed bone formation markers [bone-specific alkaline phosphatase (bALP), osteocalcin (OC), and N-terminal propeptide of collagen type 1 (PINP)] and bone resorption markers [C-terminal telopeptide cross links (CTX) and tartrate-resistant acid phosphatase (TRAcP 5b)]. Linear regression was used to compare age and sex-adjusted mean differences between intervention children and controls in these markers.<h4>Results</h4>Two years after the intervention was initiated (at Tanner stages 1-2), we found higher serum levels of bALP and OC, and lower serum levels of TRAcP 5b in the intervention compared with the control group. The mean difference (95% CI) was for bALP: 13.7 (2.1, 25.3) μg/L, OC: 9.1 (0.1, 18.1) μg/L, and TRAcP 5b: -2.3 (-3.9, -0.7) U/L. At Tanner stages 3-5 and after the intervention was terminated, bone turnover markers were similar in the intervention and the control children.<h4>Conclusion</h4>Daily school PA in the late prepubertal and early pubertal periods is associated with higher bone formation and lower bone resorption than school PA 1-2 times/week. In late pubertal and postpubertal periods, bone formation and resorption were similar. Termination of the intervention is not associated with adverse bone turnover, indicating that PA-induced bone mass benefits gained during growth may remain in adulthood.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T17:42:21.226Z","creation":"2025-04-04T23:03:20.652Z"},"accession":"S-EPMC9021887","cross_references":{"pubmed":["35464077"],"doi":["10.3389/fphys.2022.828508"]}}