biostudies-literatureBarton ANIHR | NIHR Oxford Biomedical Research CentreEuropean CommissionBill and Melinda Gates FoundationWellcome TrustAcademy of Medical Sciencese0038921https://www.ebi.ac.uk/biostudies/studies/S-EPMC9022534biostudies-literatureUnknown90(4)Infections with Salmonella enterica serovars Typhi and Paratyphi A cause an estimated 14 million cases of enteric fever annually. Here, the controlled nature of challenge studies is exploited to identify genetic variants associated with enteric fever susceptibility. Human challenge participants were genotyped by Illumina OmniExpress-24 BeadChip array (<i>n</i> = 176) and/or transcriptionally profiled by RNA sequencing (<i>n</i> = 174). While the study was underpowered to detect any single nucleotide polymorphisms (SNPs) significant at the whole-genome level, two SNPs within <i>CAPN14</i> and <i>MIATNB</i> were identified with <i>P</i> < 10^-5 for association with development of symptoms or bacteremia following oral S. Typhi or <i>S.</i> Paratyphi A challenge. Imputation of classiInfection and immunityGenetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers.PMC9022534092661/Z/10/ZN/ASBF005\1134090532/Z/09/ZOPP1113682OPP1084259Camara SChen LBarton AJones EBlohmke CJWaddington CPollard AJJones CDobinson HBibi SJin CDarton TCGibani MMHill JShrestha SfalseGenetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers.Infections with Salmonella enterica serovars Typhi and Paratyphi A cause an estimated 14 million cases of enteric fever annually. Here, the controlled nature of challenge studies is exploited to identify genetic variants associated with enteric fever susceptibility. Human challenge participants were genotyped by Illumina OmniExpress-24 BeadChip array (<i>n</i> = 176) and/or transcriptionally profiled by RNA sequencing (<i>n</i> = 174). While the study was underpowered to detect any single nucleotide polymorphisms (SNPs) significant at the whole-genome level, two SNPs within <i>CAPN14</i> and <i>MIATNB</i> were identified with <i>P</i> < 10^-5 for association with development of symptoms or bacteremia following oral S. Typhi or <i>S.</i> Paratyphi A challenge. Imputation of classi2022-01-01T00:00:00Z2022 Apr2026-07-14T14:22:17.558Z2025-04-06T21:48:28.131ZS-EPMC90225343525409310.1128/iai.00389-21