{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wragg D"],"funding":["Bill and Melinda Gates Foundation","Biotechnology and Biological Sciences Research Council","Academy of Medical Sciences"],"pagination":["e1010099"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9022807"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(4)"],"pubmed_abstract":["East Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Bos indicus (Boran) cattle demonstrating heritable tolerance to infection with T. parva (h2 = 0.65, s.e. 0.57). Through a linkage analysis we identify a 6 Mb genomic region on bovine chromosome 15 that is significantly associated with survival outcome following T. parva exposure. Testing this locus in an independent cohort of animals replicates this association with survival following T. parva infection. A stop gained variant in a paralogue of the FAF1 gene in this region was found to be highly associated with survival across both related and unrel"],"journal":["PLoS genetics"],"pubmed_title":["A locus conferring tolerance to Theileria infection in African cattle."],"pmcid":["PMC9022807"],"funding_grant_id":["BBS/E/D/20231760","BBS/E/D/30002275","SBF005\\1127","BBS/E/D/20002174","BBS/E/D/20002172","BB/H009515/1","OPP1127286"],"pubmed_authors":["Callaby R","Bronsvoort BMD","Prendergast JGD","Hassan M","Wragg D","Poole EJ","Ndambuki G","Sitt T","Hemmink JD","Miyunga AA","Mwaura S","Matika O","Powell J","Auty H","Morrison WI","Toye PG","Connelley T","Latre de Late P","Marshall K","Morrison LJ","Cook EAJ","Paxton EA","Njeru R","Chepkwony MC","Talenti A"],"additional_accession":[]},"is_claimable":false,"name":"A locus conferring tolerance to Theileria infection in African cattle.","description":"East Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Bos indicus (Boran) cattle demonstrating heritable tolerance to infection with T. parva (h2 = 0.65, s.e. 0.57). Through a linkage analysis we identify a 6 Mb genomic region on bovine chromosome 15 that is significantly associated with survival outcome following T. parva exposure. Testing this locus in an independent cohort of animals replicates this association with survival following T. parva infection. A stop gained variant in a paralogue of the FAF1 gene in this region was found to be highly associated with survival across both related and unrel","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-18T08:48:21.488Z","creation":"2025-02-19T03:27:34.507Z"},"accession":"S-EPMC9022807","cross_references":{"pubmed":["35446841"],"doi":["10.1371/journal.pgen.1010099"]}}