biostudies-literatureKaze ADJackson State UniversityNIDDK NIH HHSNHLBI NIH HHSNIMHD NIH HHSe14465https://www.ebi.ac.uk/biostudies/studies/S-EPMC9023067biostudies-literatureUnknown38(5)<h4>Aim</h4>To evaluate the association between plasma biomarkers including leptin, adiponectin, adiponectin-to-leptin ratio and high-sensitivity C-reactive protein (hsCRP) with risk of glycaemic progression and incident dysglycaemia (pre-diabetes or diabetes) in a community-based sample of African American (AAs).<h4>Methods</h4>We analysed data from 3223 participants without type 2 diabetes at baseline (2000-2004) who attended ≥1 follow-up visit. Poisson regression was used to generate risk ratios (RRs) for glycaemic progression and incident dysglycaemia.<h4>Results</h4>Over a median of 7 years, 46.4% developed glycaemic progression (n=1495). After adjusting for demographic and lifestyle variables, the RRs (95% CI) for glycaemic progression comparing highest (Q4) to lowest (Q1) quartiles Diabetic medicine : a journal of the British Diabetic AssociationPlasma adipokines and glycaemic progression among African Americans: Findings from the Jackson Heart Study.PMC9023067HHSN268201800015IHHSN268201800012CHHSN268201800011CK23 DK117041HHSN268201800012IHHSN268201800011IHHSN268201800014IHHSN268201800013IHHSN268201800010IHHSN268201800014CBertoni AGNdumele CEAhima RSEchouffo-Tcheugui JBMusani SKGolden SHCorrea AJoseph JJKaze ADBidulescu AfalsePlasma adipokines and glycaemic progression among African Americans: Findings from the Jackson Heart Study.<h4>Aim</h4>To evaluate the association between plasma biomarkers including leptin, adiponectin, adiponectin-to-leptin ratio and high-sensitivity C-reactive protein (hsCRP) with risk of glycaemic progression and incident dysglycaemia (pre-diabetes or diabetes) in a community-based sample of African American (AAs).<h4>Methods</h4>We analysed data from 3223 participants without type 2 diabetes at baseline (2000-2004) who attended ≥1 follow-up visit. Poisson regression was used to generate risk ratios (RRs) for glycaemic progression and incident dysglycaemia.<h4>Results</h4>Over a median of 7 years, 46.4% developed glycaemic progression (n=1495). After adjusting for demographic and lifestyle variables, the RRs (95% CI) for glycaemic progression comparing highest (Q4) to lowest (Q1) quartiles 2021-01-01T00:00:00Z2021 May2025-04-25T22:56:21.321Z2025-04-06T09:14:35.206ZS-EPMC90230673323637010.1111/dme.14465