{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amaral AG"],"funding":["Fundação de Amparo à Pesquisa Do Estado de São Paulo","Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior"],"pagination":["836478"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9023746"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["Cardiovascular diseases (CVDs) are noncommunicable diseases known for their complex etiology and high mortality rate. Oxidative stress (OS), a condition in which the release of free radical exceeds endogenous antioxidant capacity, is pivotal in CVC, such as myocardial infarction, ischemia/reperfusion, and heart failure. Due to the lack of information about the implications of OS on cardiovascular conditions, several methodologies have been applied to investigate the causes and consequences, and to find new ways of diagnosis and treatment as well. In the present study, cardiac dysfunction was evaluated by analyzing cells' alterations with untargeted metabolomics, after simulation of an oxidative stress condition using hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in H9c2 myocytes. Optimiza"],"journal":["Frontiers in chemistry"],"pubmed_title":["Comprehending Cardiac Dysfunction by Oxidative Stress: Untargeted Metabolomics of <i>In Vitro</i> Samples."],"pmcid":["PMC9023746"],"funding_grant_id":["Finance Code 001","2014/50244-6 2016/07014-5 2018/07383-6 2020/05965-8","406064/2018-05 42.3228/2018-8"],"pubmed_authors":["Amaral AG","Rocha I","Zandonadi FDS","Simionato AVC","Zamora-Obando HR","Sussulini A","Oliveira RV","Moretto IA","de Thomaz AA","Dos Santos AM"],"additional_accession":[]},"is_claimable":false,"name":"Comprehending Cardiac Dysfunction by Oxidative Stress: Untargeted Metabolomics of <i>In Vitro</i> Samples.","description":"Cardiovascular diseases (CVDs) are noncommunicable diseases known for their complex etiology and high mortality rate. Oxidative stress (OS), a condition in which the release of free radical exceeds endogenous antioxidant capacity, is pivotal in CVC, such as myocardial infarction, ischemia/reperfusion, and heart failure. Due to the lack of information about the implications of OS on cardiovascular conditions, several methodologies have been applied to investigate the causes and consequences, and to find new ways of diagnosis and treatment as well. In the present study, cardiac dysfunction was evaluated by analyzing cells' alterations with untargeted metabolomics, after simulation of an oxidative stress condition using hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in H9c2 myocytes. Optimiza","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-29T03:11:49.722Z","creation":"2024-11-13T07:37:21.36Z"},"accession":"S-EPMC9023746","cross_references":{"pubmed":["35464220"],"doi":["10.3389/fchem.2022.836478"]}}