biostudies-literatureUnknown13Zhu JLate blight is one of the main biological stresses limiting the potato yield; however, the biochemical mechanisms underlying the infection process of <i>Phytophthora infestans</i> remain unrevealed. In this study, the late blight-resistant potato cultivar Ziyun No.1 (R) and the susceptible cultivar Favorita (S) were inoculated with <i>P. infestans</i>. Untargeted metabolomics was used to study the changes of metabolites in the compatible and incompatible interactions of the two cultivars and the pathogen at 0, 48, and 96 h postinoculation (hpi). A total of 819 metabolites were identified, and the metabolic differences mainly emerged after 48 hpi. There were 198 and 115 differentially expressed metabolites (DEMs) in the compatible and incompatible interactions. These included 147 and 100 upFrontiers in microbiology857160https://www.ebi.ac.uk/biostudies/studies/S-EPMC9024415biostudies-literatureComparative Metabolomic Profiling of Compatible and Incompatible Interactions Between Potato and <i>Phytophthora infestans</i>.PMC9024415Jiang YLi HLi YShao HZhu JTao XWang YSun YYong BTang XfalseComparative Metabolomic Profiling of Compatible and Incompatible Interactions Between Potato and <i>Phytophthora infestans</i>.Late blight is one of the main biological stresses limiting the potato yield; however, the biochemical mechanisms underlying the infection process of <i>Phytophthora infestans</i> remain unrevealed. In this study, the late blight-resistant potato cultivar Ziyun No.1 (R) and the susceptible cultivar Favorita (S) were inoculated with <i>P. infestans</i>. Untargeted metabolomics was used to study the changes of metabolites in the compatible and incompatible interactions of the two cultivars and the pathogen at 0, 48, and 96 h postinoculation (hpi). A total of 819 metabolites were identified, and the metabolic differences mainly emerged after 48 hpi. There were 198 and 115 differentially expressed metabolites (DEMs) in the compatible and incompatible interactions. These included 147 and 100 up2022-01-01T00:00:00Z20222026-04-08T17:32:11.507Z2024-11-11T23:32:00.293ZS-EPMC90244153546490810.3389/fmicb.2022.857160