{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Charoensaensuk V"],"funding":["Ministry of Science and Technology","China Medical University","China Medical University Hospital"],"pagination":["740"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9024880"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["We recently reported that the periodontopathic bacteria <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) initiates an inflammatory cascade that disrupts the balance of reactive oxygen species (ROS), resulting in apoptotic cell death in brain endothelial cells. An extract from <i>Polygonum multiflorum</i> Thunb., 2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside (THSG) has been well-reported to diminish the inflammation in many disease models. However, the effects of THSG in the area of the brain-oral axis is unknown. In this study, we examined the effects of THSG in <i>P. gingivalis</i>-stimulated inflammatory response and apoptotic cell death in brain endothelial cells. THSG treatment remarkably lessened the upregulation of IL-1β and TNF-α proteins in bEnd.3 cells infected with <i>P. gi"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside Attenuates Reactive Oxygen Species-Dependent Inflammation and Apoptosis in <i>Porphyromonas gingivalis</i>-Infected Brain Endothelial Cells."],"pmcid":["PMC9024880"],"funding_grant_id":["DMR-110-120","DMR-110-096","CMU109-MF-80","MOST 109-2927-I-039-001","DMR-110-048","MOST 110-2622-8-039-004-TB1","CMU109-S-14"],"pubmed_authors":["Yang LY","Lin YH","Ou KL","Chen YC","Lu DY","Charoensaensuk V"],"additional_accession":[]},"is_claimable":false,"name":"2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside Attenuates Reactive Oxygen Species-Dependent Inflammation and Apoptosis in <i>Porphyromonas gingivalis</i>-Infected Brain Endothelial Cells.","description":"We recently reported that the periodontopathic bacteria <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) initiates an inflammatory cascade that disrupts the balance of reactive oxygen species (ROS), resulting in apoptotic cell death in brain endothelial cells. An extract from <i>Polygonum multiflorum</i> Thunb., 2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside (THSG) has been well-reported to diminish the inflammation in many disease models. However, the effects of THSG in the area of the brain-oral axis is unknown. In this study, we examined the effects of THSG in <i>P. gingivalis</i>-stimulated inflammatory response and apoptotic cell death in brain endothelial cells. THSG treatment remarkably lessened the upregulation of IL-1β and TNF-α proteins in bEnd.3 cells infected with <i>P. gi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-06-01T12:12:02.8Z","creation":"2025-02-19T03:58:11.805Z"},"accession":"S-EPMC9024880","cross_references":{"pubmed":["35453424"],"doi":["10.3390/antiox11040740"]}}