biostudies-literatureCharoensaensuk VMinistry of Science and TechnologyChina Medical UniversityChina Medical University Hospital740https://www.ebi.ac.uk/biostudies/studies/S-EPMC9024880biostudies-literatureUnknown11(4)We recently reported that the periodontopathic bacteria <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) initiates an inflammatory cascade that disrupts the balance of reactive oxygen species (ROS), resulting in apoptotic cell death in brain endothelial cells. An extract from <i>Polygonum multiflorum</i> Thunb., 2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside (THSG) has been well-reported to diminish the inflammation in many disease models. However, the effects of THSG in the area of the brain-oral axis is unknown. In this study, we examined the effects of THSG in <i>P. gingivalis</i>-stimulated inflammatory response and apoptotic cell death in brain endothelial cells. THSG treatment remarkably lessened the upregulation of IL-1β and TNF-α proteins in bEnd.3 cells infected with <i>P. giAntioxidants (Basel, Switzerland)2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside Attenuates Reactive Oxygen Species-Dependent Inflammation and Apoptosis in <i>Porphyromonas gingivalis</i>-Infected Brain Endothelial Cells.PMC9024880DMR-110-120DMR-110-096CMU109-MF-80MOST 109-2927-I-039-001DMR-110-048MOST 110-2622-8-039-004-TB1CMU109-S-14Yang LYLin YHOu KLChen YCLu DYCharoensaensuk Vfalse2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside Attenuates Reactive Oxygen Species-Dependent Inflammation and Apoptosis in <i>Porphyromonas gingivalis</i>-Infected Brain Endothelial Cells.We recently reported that the periodontopathic bacteria <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) initiates an inflammatory cascade that disrupts the balance of reactive oxygen species (ROS), resulting in apoptotic cell death in brain endothelial cells. An extract from <i>Polygonum multiflorum</i> Thunb., 2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside (THSG) has been well-reported to diminish the inflammation in many disease models. However, the effects of THSG in the area of the brain-oral axis is unknown. In this study, we examined the effects of THSG in <i>P. gingivalis</i>-stimulated inflammatory response and apoptotic cell death in brain endothelial cells. THSG treatment remarkably lessened the upregulation of IL-1β and TNF-α proteins in bEnd.3 cells infected with <i>P. gi2022-01-01T00:00:00Z2022 Apr2025-06-01T12:12:02.8Z2025-02-19T03:58:11.805ZS-EPMC90248803545342410.3390/antiox11040740