biostudies-literatureXie YQingdao National Laboratory for Marine Science and Technologythe National Key R and D Program of Chinathe National Natural Science Foundation of China651https://www.ebi.ac.uk/biostudies/studies/S-EPMC9025465biostudies-literatureUnknown13(4)Salinity is a critical abiotic factor for all living organisms. The ability to adapt to different salinity environments determines an organism's survival and ecological niches. <i>Litoditis marina</i> is a euryhaline marine nematode widely distributed in coastal ecosystems all over the world, although numerous genes involved in its salinity response have been reported, the adaptive mechanisms underlying its euryhalinity remain unexplored. Here, we utilized worms which have been acclimated to either low-salinity or high-salinity conditions and evaluated their basal gene expression at both transcriptomic and proteomic levels. We found that several conserved regulators, including osmolytes biosynthesis genes, transthyretin-like family genes, V-type H⁺-transporting ATPase and potassGenesTranscriptomic and Proteomic Analysis of Marine Nematode <i>Litoditis marina</i> Acclimated to Different Salinities.PMC9025465No. YQ2018NO10[to L.Z.]No. 41806169Grant 16-8-3-19-zhcNo. 2018YFD0901301Xie YZhang LfalseTranscriptomic and Proteomic Analysis of Marine Nematode <i>Litoditis marina</i> Acclimated to Different Salinities.Salinity is a critical abiotic factor for all living organisms. The ability to adapt to different salinity environments determines an organism's survival and ecological niches. <i>Litoditis marina</i> is a euryhaline marine nematode widely distributed in coastal ecosystems all over the world, although numerous genes involved in its salinity response have been reported, the adaptive mechanisms underlying its euryhalinity remain unexplored. Here, we utilized worms which have been acclimated to either low-salinity or high-salinity conditions and evaluated their basal gene expression at both transcriptomic and proteomic levels. We found that several conserved regulators, including osmolytes biosynthesis genes, transthyretin-like family genes, V-type H⁺-transporting ATPase and potass2022-01-01T00:00:00Z2022 Apr2025-05-31T23:43:15.638Z2025-05-31T23:43:15.638ZS-EPMC90254653545645810.3390/genes13040651