{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(15)"],"submitter":["Farrukh M"],"pubmed_abstract":["Traditionally, <i>Sarcococca saligna</i> has been used for the treatment of arthritis and many other inflammatory disorders. The current study was planned to give scientific evidence to this traditional use of <i>S. saligna.</i> Phytochemical profiling of SSME was carried out by using electrospray ionization mass spectrometry (ESI-MS/MS). Complete Freund's adjuvant (CFA), 150 μL was injected in the subplantar region of the left hind paw to induce arthritis in rats. Aqueous methanolic extract of <i>S. saligna</i> (SSME) was administered orally at 250, 500, or 1000 mg/kg dose from the 7th day to the 28th day of the study to explore its anti-arthritic potential. Histopathological and radiographic assessment of joints and enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain"],"journal":["ACS omega"],"pagination":["13164-13177"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9026066"],"repository":["biostudies-literature"],"pubmed_title":["<i>Sarcococca saligna</i> Hydroalcoholic Extract Ameliorates Arthritis in Complete Freund's Adjuvant-Induced Arthritic Rats via Modulation of Inflammatory Biomarkers and Suppression of Oxidative Stress Markers."],"pmcid":["PMC9026066"],"pubmed_authors":["Qasim M","Ahmad B","Alhasani RH","Manan M","Alsharif I","Shah GM","Shah MA","Saleem U","Chauhdary Z","Farrukh M"],"additional_accession":[]},"is_claimable":false,"name":"<i>Sarcococca saligna</i> Hydroalcoholic Extract Ameliorates Arthritis in Complete Freund's Adjuvant-Induced Arthritic Rats via Modulation of Inflammatory Biomarkers and Suppression of Oxidative Stress Markers.","description":"Traditionally, <i>Sarcococca saligna</i> has been used for the treatment of arthritis and many other inflammatory disorders. The current study was planned to give scientific evidence to this traditional use of <i>S. saligna.</i> Phytochemical profiling of SSME was carried out by using electrospray ionization mass spectrometry (ESI-MS/MS). Complete Freund's adjuvant (CFA), 150 μL was injected in the subplantar region of the left hind paw to induce arthritis in rats. Aqueous methanolic extract of <i>S. saligna</i> (SSME) was administered orally at 250, 500, or 1000 mg/kg dose from the 7th day to the 28th day of the study to explore its anti-arthritic potential. Histopathological and radiographic assessment of joints and enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T09:20:31.872Z","creation":"2025-04-04T09:20:31.872Z"},"accession":"S-EPMC9026066","cross_references":{"pubmed":["35474846"],"doi":["10.1021/acsomega.2c00619"]}}