biostudies-literatureUnknown7(15)Farrukh MTraditionally, <i>Sarcococca saligna</i> has been used for the treatment of arthritis and many other inflammatory disorders. The current study was planned to give scientific evidence to this traditional use of <i>S. saligna.</i> Phytochemical profiling of SSME was carried out by using electrospray ionization mass spectrometry (ESI-MS/MS). Complete Freund's adjuvant (CFA), 150 μL was injected in the subplantar region of the left hind paw to induce arthritis in rats. Aqueous methanolic extract of <i>S. saligna</i> (SSME) was administered orally at 250, 500, or 1000 mg/kg dose from the 7th day to the 28th day of the study to explore its anti-arthritic potential. Histopathological and radiographic assessment of joints and enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chainACS omega13164-13177https://www.ebi.ac.uk/biostudies/studies/S-EPMC9026066biostudies-literature<i>Sarcococca saligna</i> Hydroalcoholic Extract Ameliorates Arthritis in Complete Freund's Adjuvant-Induced Arthritic Rats via Modulation of Inflammatory Biomarkers and Suppression of Oxidative Stress Markers.PMC9026066Qasim MAhmad BAlhasani RHManan MAlsharif IShah GMShah MASaleem UChauhdary ZFarrukh Mfalse<i>Sarcococca saligna</i> Hydroalcoholic Extract Ameliorates Arthritis in Complete Freund's Adjuvant-Induced Arthritic Rats via Modulation of Inflammatory Biomarkers and Suppression of Oxidative Stress Markers.Traditionally, <i>Sarcococca saligna</i> has been used for the treatment of arthritis and many other inflammatory disorders. The current study was planned to give scientific evidence to this traditional use of <i>S. saligna.</i> Phytochemical profiling of SSME was carried out by using electrospray ionization mass spectrometry (ESI-MS/MS). Complete Freund's adjuvant (CFA), 150 μL was injected in the subplantar region of the left hind paw to induce arthritis in rats. Aqueous methanolic extract of <i>S. saligna</i> (SSME) was administered orally at 250, 500, or 1000 mg/kg dose from the 7th day to the 28th day of the study to explore its anti-arthritic potential. Histopathological and radiographic assessment of joints and enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain2022-01-01T00:00:00Z2022 Apr2025-04-04T09:20:31.872Z2025-04-04T09:20:31.872ZS-EPMC90260663547484610.1021/acsomega.2c00619