{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(4)"],"submitter":["Abbes S"],"pubmed_abstract":["The neurotoxic alkaloid β-N-methyl-amino-l-alanine (BMAA) and related isomers, including N-(2-aminoethyl glycine) (AEG), β-amino-N-methyl alanine (BAMA), and 2,4-diaminobutyric acid (DAB), have been reported previously in cyanobacterial samples. However, there are conflicting reports regarding their occurrence in surface waters. In this study, we evaluated the impact of amending lake water samples with trichloroacetic acid (0.1 M TCA) on the detection of BMAA isomers, compared with pre-existing protocols. A sensitive instrumental method was enlisted for the survey, with limits of detection in the range of 5-10 ng L<sup>-1</sup>. Higher detection rates and significantly greater levels (paired Wilcoxon's signed-rank tests, <i>p</i> &lt; 0.001) of BMAA isomers were observed in TCA-amended sam"],"journal":["Toxins"],"pagination":["251"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9026818"],"repository":["biostudies-literature"],"pubmed_title":["Occurrence of BMAA Isomers in Bloom-Impacted Lakes and Reservoirs of Brazil, Canada, France, Mexico, and the United Kingdom."],"pmcid":["PMC9026818"],"pubmed_authors":["Venkiteswaran JJ","Husk B","Abbes S","Larsen ML","Giani A","Lowe CD","Munoz G","Simon DF","Dinh QT","Vincon-Leite B","Baulch HM","Martinez Jeronimo FF","Sauve S","Greer CW","Fortin N","Tromas N","Vo Duy S"],"additional_accession":[]},"is_claimable":false,"name":"Occurrence of BMAA Isomers in Bloom-Impacted Lakes and Reservoirs of Brazil, Canada, France, Mexico, and the United Kingdom.","description":"The neurotoxic alkaloid β-N-methyl-amino-l-alanine (BMAA) and related isomers, including N-(2-aminoethyl glycine) (AEG), β-amino-N-methyl alanine (BAMA), and 2,4-diaminobutyric acid (DAB), have been reported previously in cyanobacterial samples. However, there are conflicting reports regarding their occurrence in surface waters. In this study, we evaluated the impact of amending lake water samples with trichloroacetic acid (0.1 M TCA) on the detection of BMAA isomers, compared with pre-existing protocols. A sensitive instrumental method was enlisted for the survey, with limits of detection in the range of 5-10 ng L<sup>-1</sup>. Higher detection rates and significantly greater levels (paired Wilcoxon's signed-rank tests, <i>p</i> &lt; 0.001) of BMAA isomers were observed in TCA-amended sam","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-05T13:23:41.056Z","creation":"2025-04-05T13:23:41.056Z"},"accession":"S-EPMC9026818","cross_references":{"pubmed":["35448860"],"doi":["10.3390/toxins14040251"]}}