{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(8)"],"submitter":["Swietlik D"],"pubmed_abstract":["(1) Background: in patients with neurodegenerative diseases, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists provide neuroprotective advantages. We performed memantine therapy and proved mathematical and computer modeling of neurodegenerative disease in this study. (2) Methods: a computer simulation environment of the N-methyl-D-aspartate receptor incorporating biological mechanisms of channel activation by high extracellular glutamic acid concentration. In comparison to controls, pathological models were essentially treated with doses of memantine 3-30 µM. (3) Results: the mean values and 95% CI for Shannon entropy in Alzheimer's disease (AD) and memantine treatment models were 1.760 (95% CI, 1.704-1.818) vs. 2.385 (95% CI, 2.280-2.490). The Shannon entropy was significant"],"journal":["International journal of environmental research and public health"],"pagination":["4727"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9027074"],"repository":["biostudies-literature"],"pubmed_title":["Computational Modeling of Therapy with the NMDA Antagonist in Neurodegenerative Disease: Information Theory in the Mechanism of Action of Memantine."],"pmcid":["PMC9027074"],"pubmed_authors":["Kusiak A","Ossowska A","Swietlik D"],"additional_accession":[]},"is_claimable":false,"name":"Computational Modeling of Therapy with the NMDA Antagonist in Neurodegenerative Disease: Information Theory in the Mechanism of Action of Memantine.","description":"(1) Background: in patients with neurodegenerative diseases, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists provide neuroprotective advantages. We performed memantine therapy and proved mathematical and computer modeling of neurodegenerative disease in this study. (2) Methods: a computer simulation environment of the N-methyl-D-aspartate receptor incorporating biological mechanisms of channel activation by high extracellular glutamic acid concentration. In comparison to controls, pathological models were essentially treated with doses of memantine 3-30 µM. (3) Results: the mean values and 95% CI for Shannon entropy in Alzheimer's disease (AD) and memantine treatment models were 1.760 (95% CI, 1.704-1.818) vs. 2.385 (95% CI, 2.280-2.490). The Shannon entropy was significant","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-05T13:23:50.188Z","creation":"2025-04-05T13:23:50.188Z"},"accession":"S-EPMC9027074","cross_references":{"pubmed":["35457595"],"doi":["10.3390/ijerph19084727"]}}