{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fu X"],"funding":["The Francis Crick Institute"],"pagination":["1334"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9027133"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(8)"],"pubmed_abstract":["G-protein-coupled receptors (GPCRs) remain one of the most successful targets for therapeutic drugs approved by the US Food and Drug Administration (FDA). Many novel orphan GPCRs have been identified by human genome sequencing and considered as putative targets for refractory diseases. Of note, a series of studies have been carried out involving GPCR 158 (or GPR158) since its identification in 2005, predominantly focusing on the characterization of its roles in the progression of cancer and mental illness. However, advances towards an in-depth understanding of the biological mechanism(s) involved for clinical application of GPR158 are lacking. In this paper, we clarify the origin of the GPR158 evolution in different species and summarize the relationship between GPR158 and different diseas"],"journal":["Cells"],"pubmed_title":["Research Status of the Orphan G Protein Coupled Receptor 158 and Future Perspectives."],"pmcid":["PMC9027133"],"funding_grant_id":["10017"],"pubmed_authors":["Yang G","Fan H","Costa CD","Pan Y","He Y","Fu X","Zhang Y","Wei S","Wang T","Brandner S","Li N"],"additional_accession":[]},"is_claimable":false,"name":"Research Status of the Orphan G Protein Coupled Receptor 158 and Future Perspectives.","description":"G-protein-coupled receptors (GPCRs) remain one of the most successful targets for therapeutic drugs approved by the US Food and Drug Administration (FDA). Many novel orphan GPCRs have been identified by human genome sequencing and considered as putative targets for refractory diseases. Of note, a series of studies have been carried out involving GPCR 158 (or GPR158) since its identification in 2005, predominantly focusing on the characterization of its roles in the progression of cancer and mental illness. However, advances towards an in-depth understanding of the biological mechanism(s) involved for clinical application of GPR158 are lacking. In this paper, we clarify the origin of the GPR158 evolution in different species and summarize the relationship between GPR158 and different diseas","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-05T15:23:11.115Z","creation":"2025-04-05T15:23:11.115Z"},"accession":"S-EPMC9027133","cross_references":{"pubmed":["35456013"],"doi":["10.3390/cells11081334"]}}