{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin JX"],"funding":["National Natural Science Foundation of China","Excellent Youth Project of Heilongjiang Province Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["687"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9027243"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["Previous studies suggest that the inclusion of melatonin (MTn) in in vitro maturation protocols improves the developmental competence of oocytes by scavenging reactive oxygen species (ROS). However, the molecular mechanisms integrating melatonin receptor (MT)-mediated lipid metabolism and redox signaling during in vitro cumulus-oocyte complex (COC) development still remain unclear. Here, we aimed to elucidate the potential role of MTn receptors in lipid metabolic adjustments during in vitro porcine COC development. We observed that MTn-mediated G<sub>s</sub>α-cAMP/PKA signaling facilitated lipolysis primarily through the MT2 receptor and subsequently increased fatty acid (FA) release by hydrolyzing intracellular triglycerides (TGs) in cumulus cells. Furthermore, <i>CD36</i> was a critical "],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Melatonin Regulates Lipid Metabolism in Porcine Cumulus-Oocyte Complexes via the Melatonin Receptor 2."],"pmcid":["PMC9027243"],"funding_grant_id":["YQ2020C007","31872360","32002179","2021YFA0805902"],"pubmed_authors":["Cui HD","Lee S","Bian Y","Lee BC","Sun JT","Jiang CQ","Zhang L","Liu ZH","Jin JX"],"additional_accession":[]},"is_claimable":false,"name":"Melatonin Regulates Lipid Metabolism in Porcine Cumulus-Oocyte Complexes via the Melatonin Receptor 2.","description":"Previous studies suggest that the inclusion of melatonin (MTn) in in vitro maturation protocols improves the developmental competence of oocytes by scavenging reactive oxygen species (ROS). However, the molecular mechanisms integrating melatonin receptor (MT)-mediated lipid metabolism and redox signaling during in vitro cumulus-oocyte complex (COC) development still remain unclear. Here, we aimed to elucidate the potential role of MTn receptors in lipid metabolic adjustments during in vitro porcine COC development. We observed that MTn-mediated G<sub>s</sub>α-cAMP/PKA signaling facilitated lipolysis primarily through the MT2 receptor and subsequently increased fatty acid (FA) release by hydrolyzing intracellular triglycerides (TGs) in cumulus cells. Furthermore, <i>CD36</i> was a critical ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-06T19:48:20.46Z","creation":"2025-04-06T19:48:20.46Z"},"accession":"S-EPMC9027243","cross_references":{"pubmed":["35453372"],"doi":["10.3390/antiox11040687"]}}