{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Albasanz-Puig A"],"funding":["Instituto de Salud Carlos III"],"pagination":["733"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9027680"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(4)"],"pubmed_abstract":["To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with <i>Pseudomonas aeruginosa</i> (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006-2018). The effect of appropriate empirical combination therapy, appropriate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant (MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain [38/52 (73.1%) "],"journal":["Microorganisms"],"pubmed_title":["Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with <i>Pseudomonas aeruginosa</i> Pneumonia."],"pmcid":["PMC9027680"],"funding_grant_id":["CB21/13/00009, CB21/13/00079, CB21/13/00054, CB21/13/00086, CB21/13/00012"],"pubmed_authors":["Martin-Davila P","Hemmati P","Tilley R","Dura-Miralles X","Albasanz-Puig A","Carratala J","Aguado JM","Kern WV","Mussetti A","Araos R","Puerta-Alcalde P","Herrera F","Novo A","Ruiz-Camps I","Gomes MZR","Montero M","Drgona L","Del Pozo JL","Morales HMP","Gudiol C","Laporte-Amargos J","Mikulska M","Retamar-Gentil P","Akova M","Pallares N","Manzur A","Abdala E","Marin JI","Calik S","Peghin M","Yanez L","On Behalf Of The Ironic Study Group","Gasch O","Sipahi OR","Bergas A","Garcia E","Isler B","Kanj SS","Oltolini C","Montejo JM","Brunel AS","Marquez-Gomez I"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with <i>Pseudomonas aeruginosa</i> Pneumonia.","description":"To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with <i>Pseudomonas aeruginosa</i> (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006-2018). The effect of appropriate empirical combination therapy, appropriate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant (MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain [38/52 (73.1%) ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-05-18T12:07:29.408Z","creation":"2025-02-19T03:58:32.589Z"},"accession":"S-EPMC9027680","cross_references":{"pubmed":["35456784"],"doi":["10.3390/microorganisms10040733"]}}