biostudies-literatureAlbasanz-Puig AInstituto de Salud Carlos III733https://www.ebi.ac.uk/biostudies/studies/S-EPMC9027680biostudies-literatureUnknown10(4)To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with <i>Pseudomonas aeruginosa</i> (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006-2018). The effect of appropriate empirical combination therapy, appropriate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant (MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain [38/52 (73.1%) MicroorganismsEffect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with <i>Pseudomonas aeruginosa</i> Pneumonia.PMC9027680CB21/13/00009, CB21/13/00079, CB21/13/00054, CB21/13/00086, CB21/13/00012Martin-Davila PHemmati PTilley RDura-Miralles XAlbasanz-Puig ACarratala JAguado JMKern WVMussetti AAraos RPuerta-Alcalde PHerrera FNovo ARuiz-Camps IGomes MZRMontero MDrgona LDel Pozo JLMorales HMPGudiol CLaporte-Amargos JMikulska MRetamar-Gentil PAkova MPallares NManzur AAbdala EMarin JICalik SPeghin MYanez LOn Behalf Of The Ironic Study GroupGasch OSipahi ORBergas AGarcia EIsler BKanj SSOltolini CMontejo JMBrunel ASMarquez-Gomez IfalseEffect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with <i>Pseudomonas aeruginosa</i> Pneumonia.To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with <i>Pseudomonas aeruginosa</i> (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006-2018). The effect of appropriate empirical combination therapy, appropriate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant (MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain [38/52 (73.1%) 2022-01-01T00:00:00Z2022 Mar2025-05-18T12:07:29.408Z2025-02-19T03:58:32.589ZS-EPMC90276803545678410.3390/microorganisms10040733