biostudies-literatureVargas-Alarcon GInstituto Nacional de Cardiologia Ignacio Chavez486https://www.ebi.ac.uk/biostudies/studies/S-EPMC9027896biostudies-literatureUnknown12(4)We conducted a case-control study in order to evaluate whether <i>ABO</i> gene polymorphisms were associated with a high risk of developing COVID-19 in a cohort of patients. Six <i>ABO</i> gene polymorphisms (rs651007 <i>T</i>/<i>C</i>, rs579459 <i>T</i>/<i>C</i>, rs495828 <i>T/G</i>, rs8176746 <i>A/C</i>, rs8176740 <i>T/A</i>, and rs512770 <i>T</i>/<i>C</i>) were determined using TaqMan genotyping assays in a group of 415 COVID-19 patients and 288 healthy controls. The distribution of rs651007 <i>T</i>/<i>C</i>, rs579459 <i>T</i>/<i>C</i>, rs495828 <i>T</i>/<i>G</i>, and rs8176746 <i>A</i>/<i>C</i> polymorphisms was similar in patients and healthy controls. Nonetheless, under co-dominant (OR = 1.89, pC_Co-dominant = 6 × 10^-6), recessive (OR = 1.98, pC<sub>Recessive</sBiomoleculesThe rs8176740 <i>T/A</i> and rs512770 <i>T/C</i> Genetic Variants of the <i>ABO</i> Gene Increased the Risk of COVID-19, as well as the Plasma Concentration Platelets.PMC9027896Project-21-1237Ramirez-Bello JPosadas-Sanchez RRojas-Velasco GOrtega-Pena SArellano-Gonzalez MFragoso JMMontufar-Robles IVargas-Alarcon GLopez-Reyes AMartinez-Gomez LBarbosa-Cobos REfalseThe rs8176740 <i>T/A</i> and rs512770 <i>T/C</i> Genetic Variants of the <i>ABO</i> Gene Increased the Risk of COVID-19, as well as the Plasma Concentration Platelets.We conducted a case-control study in order to evaluate whether <i>ABO</i> gene polymorphisms were associated with a high risk of developing COVID-19 in a cohort of patients. Six <i>ABO</i> gene polymorphisms (rs651007 <i>T</i>/<i>C</i>, rs579459 <i>T</i>/<i>C</i>, rs495828 <i>T/G</i>, rs8176746 <i>A/C</i>, rs8176740 <i>T/A</i>, and rs512770 <i>T</i>/<i>C</i>) were determined using TaqMan genotyping assays in a group of 415 COVID-19 patients and 288 healthy controls. The distribution of rs651007 <i>T</i>/<i>C</i>, rs579459 <i>T</i>/<i>C</i>, rs495828 <i>T</i>/<i>G</i>, and rs8176746 <i>A</i>/<i>C</i> polymorphisms was similar in patients and healthy controls. Nonetheless, under co-dominant (OR = 1.89, pC_Co-dominant = 6 × 10^-6), recessive (OR = 1.98, pC<sub>Recessive</s2022-01-01T00:00:00Z2022 Mar2025-06-01T00:50:50.943Z2024-11-13T11:05:35.397ZS-EPMC90278963545407510.3390/biom12040486