{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Messina NL"],"funding":["Swiss National Science Foundation","National Health and Medical Research Council","Minderoo Foundation","Bill and Melinda Gates Foundation","Royal Children&apos;s Hospital Foundation"],"pagination":["e1387"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9028103"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["<h4>Background and objectives</h4>Because of its beneficial off-target effects against non-mycobacterial infectious diseases, bacillus Calmette-Guérin (BCG) vaccination might be an accessible early intervention to boost protection against novel pathogens. Multiple epidemiological studies and randomised controlled trials (RCTs) are investigating the protective effect of BCG against coronavirus disease 2019 (COVID-19). Using samples from participants in a placebo-controlled RCT aiming to determine whether BCG vaccination reduces the incidence and severity of COVID-19, we investigated the immunomodulatory effects of BCG on <i>in vitro</i> immune responses to SARS-CoV-2.<h4>Methods</h4>This study used peripheral blood taken from participants in the multicentre RCT and BCG vaccination to reduce"],"journal":["Clinical & translational immunology"],"pubmed_title":["Off-target effects of bacillus Calmette-Guerin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19."],"pmcid":["PMC9028103"],"funding_grant_id":["P2GEP3_178155","GNT1197117","GNT1177174","COV‐001","2020‐1263","INV‐017302"],"pubmed_authors":["Young A","Pelayo L","Rodrigues T","Serrano R","Dawe P","Shave M","Douglas M","Gardiner K","Al-Hindawi Y","Prajitno E","Rodrigues L","Barbosa AAR","van der Waal M","Gardiner E","Escobar RCD","Paterson D","Glenn P","Gladanac B","Herrmann S","Molenaar K","Manning L","Walker M","Meek B","Judith S","Vidmar S","Silva EF","Mojeed J","Romme J","Barros D","Finn A","Fernandes IR","Wee-Hee A","Baulman T","Jimenez VP","Rodrigues B","Bergant N","Bennett-Wood V","Santos D","Sondag T","Meehan A","Fletcher E","Keeble T","Bartlett A","Hassing RJ","Oliveira MG","Valero O","Freitas T","Roescher N","Santos T","Baena AS","Gomes A","Lieschke K","Villar R","Miller S","Lalich D","Rhodes S","Seamark C","van Den Heuvel L","Arruda BMSM","Meireles PLG","Gutierrez ABM","Font MR","Wedderburn J","Dang T","Jenkins N","Verheij H","Galletta L","Oppedisano F","da Costa Silva R","Rosell A","Mead L","Huijbens D","Cheah J","Janssen A","Quinn L","Marins A","de Andrade CB","Seamark D","Barry S","Wadia U","Dominguez J","Bogea CL","Malley R","Sterling K","Symons L","Onysk J","van Onzenoort H","Marti CB","Molina B","Richmond P","Abreu C","Waring J","Espindola MC","Fowler S","Messina NL","Bahaduri T","Dos Reis Pereira AASA","Molina G","Dunn R","Dos Santos CR","Carlin J","Porcuna TP","Mezzetti I","Garcia PB","Brophy C","Hilton S","Eden G","La N","Catterick H","Filius P","de Oliveira MV","Gamage D","Sharma K","Nascimento E","Rodriguez-Bano J","Peta E","Gifford A","Spry L","Junior J","Beardsley J","Machado C","Garcia C","Pereira RMP","Goldenberg T","Kluytmans J","Jarvis L","Dunn A","Ma N","da Cruz LA","Stevens L","Stevens N","Elborough H","O'Bryan J","Neeland MR","Perez C","Fouracre L","Jorge L","Perez G","Heath C","Arnold A","Webber-Rookes D","Ooi I","McMullan B","Krieg M","Marcos SG","Latorre I","Ong B","Latkovic E","Bonnici R","Muranaka S","Martin C","Prado C","Anderson J","Dao A","Gomes FMN","Vasconcelos A","Paes R","Sampaio V","Tadokoro MM","Ong J","Anthony C","Sanchez N","Castro E","Orsini F","Shen L","Vieira HMR","Chengodu T","Puga M","Gordon V","Castro R","Costa E","Siqueira M","Zwart V","Collopy S","Stewart C","Guo C","Marques RL","Mather W","Younes A","da Rosa THS","Hutton H","Parkin K","Bimboese P","Statton S","Mazurega K","Rym B","Ciaverella M","Angelo JTC","Byrne B","Sidaway-Lee K","Bustos N","Byrne A","da Silva Dos Santos AA","Ewe K","Steve L","Rocha J","Stooper L","van Opdorp M","Alamrousi A","McElroy R","Gell G","Barney S","Uffing M","Kent J","Ren J","Vega N","Casas I","Dawson D","Ganpat R","Sousa A","Mitchell K","Montgomery L","Knight B","Mitchell M","Trindade A","Curtis N","Reynolds S","Floy AP","Vennells L","Sanchez B","Finucane C","Richmond H","Dijkstra H","Wood N","Dos Santos KL","Bowes K","Colaco C","Dos Santos Lencina J","Warren R","Dalcolmo M","Godinho V","Davidson A","Esteve M","Lynn M","Singh R","Lynn D","Mathers M","Germano S","Troeman D","Lockhart G","Pandine G","Del Toro Lopez MD","Lacoma A","van Sluis N","Villanueva P","Sawka A","Rak A","Jamieson T","Ramos MM","Richards C","Hannan M","Teo JW","Warris A","Velagapudi S","Edmund H","Harrison R","Navarrette N","BRACE trial","Nelly A","Tristan E","Barrera L","de la Serna A","Del Alba Rey Morillo R","Lagunday R","Shann F","Santos GD","Goncalves LGC","Netea M","Queiroz E","Bannister S","Mulholland K","Meireles BTL","Blake S","Simao M","de Oliveira KRW","Marshall H","Preijers L","Pelser S","Ortega RV","Castellano AD","Maia B","Olivier N","Calbo E","Crawford N","Boersma W","Desylva M","Gama L","James J","Bijllaardt W","Val F","Maxwell C","Ten Oever J","Maia I","Santos AG","Gibbons M","De La Cruz K","Chern TY","Bonten M","Hall L","Tripp H","Daitiri B","Silva R","Subbarao K","de Las Revillas Almajano FA","Hall R","Andrade PH","Fahey K","Gibson C","Rico CG","Cuadra MG","Silva J","Otsuka A","Croda J","Arrowsmith B","Gwee A","Montes JC","Prat-Aymerich C","Karuppasamy H","Vlahos A","England M","Silva E","Williams P","Post J","Hamilton K","Corbett M","Cruz A","Owens R","Palasanthiran P","Ter Heine R","Kollmann T","Henare N","Dos Santos MG","Pereira G","van Mook L","Sastry A","Munns C","Dixon R","Kloeg P","Wall K","Nicholson S","Pereira H","Venton T","Carrerero JM","Cobbledick A","de Arellano ER","de Jesus Costa M","Fidler G","Faustman D","Neves J","Bealing M","Harker N","McDonald E","Agius S","McDonald F","Noonan F","Van Leusen JH","Greven F","Firth S","Capella AG","Hill E","Roque MC","Allao Chaves MSD","Perrett K","Evans N","Overton K","Benson S","Cushnahan J","Evans S","Rudraraju R","Dos Santos Silva D","Flynn L","Rol A","de Oliveira A","Flynn C","Brasil L","Czajko A","Dunnill J","Dos Santos DSL","Jones J","Jones K","Diogo RCP","Pitkin S","da Silva PVR","Alves CML","Camesella B","Suiker A","Toh R","Wallace R","Harbech H","Boon A","Markow A","Morawakage T","Hernandez AP","Oliveira T","Sooriyarachchi E","Paternotte N","Bell J","Carvalho E","Castro GCE","Moore J","Krastev A","Moorlag S","Oliveira M","Watts E","Oliveira R","Moore C","O'Donnell M","Burns A","O'Donnell L","Lim K","Moss J","Legge D","Lacerda M","Oliveira I","Jardim B","Sallent S","Joyce R","Alvarez MCF","Pon RC","McPhate N","Studham J","Pittet LF","Wesselingh S","Mazarakis N","van de Ven C","Lucas M","de Oliveira AG","Chan J","Zampieri F","Burrell E","Te Riele M","McMillan M","Newman G","Jardim T","Sartim A","Lemmers T","Wolters B","Norton W","Fairweather J","de Souza APC","Vidal S","Clark S","Comella P","Dalton K","Septer-Bijleveld E","Machingaifa F","Thomson H","McAlister S","Verhoeven PM","Silveira SAD","Lee K","Abruzzo V","Ayala WE","de Lima GT","Barriocanal A","Zhou C","Goodall C","Freitas MLS","Ortika B","Ramos CV","de Morais Batista F","Fernandez M","Moyle W","Calderon IP","Ramos P","Coya R","Gisolf J","Valls E","Buchanan S","Elia S","Elkington O","Taks E","Ginsberg A","Pell C","Barbosa FB","Leurink T","Azzopardi K","Odoi S","Wearing-Smith M","Melo R","Campos DG","Manton S","Kandasamy R","Xie I","Goikoetxea J","Barriocanal AM","Wang X","Karunanayake A","Poderos TG","McAndrews A","Tan N","Goodchild L","Botten R","Griffith L","van Rijen M","O'Connell A","Truelove A","Doran C","Cangas A","Vilegas MJR","Stiglmayer L","Batista L","Eiffler N","Addlem L","Vieira P","Batista V","Blauwendraat K","Steer A","Bourke A","Olivio L","Sudbury E","Power C","Croda MG","Rogers S","Whale B","Schultz N","Souza ARL","Ngien B","Joshi S","Korman T","Haywood Z","Bucholc J","Figueiredo LR","Furtado AC","Almeida KM","Nguyen K","Nguyen J","Harding A","Campbell J","Mena G","Perlen S","Macalister S","Mesquita D","Tsuha D","Sacca D","van der Veen S"],"additional_accession":[]},"is_claimable":false,"name":"Off-target effects of bacillus Calmette-Guerin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19.","description":"<h4>Background and objectives</h4>Because of its beneficial off-target effects against non-mycobacterial infectious diseases, bacillus Calmette-Guérin (BCG) vaccination might be an accessible early intervention to boost protection against novel pathogens. Multiple epidemiological studies and randomised controlled trials (RCTs) are investigating the protective effect of BCG against coronavirus disease 2019 (COVID-19). Using samples from participants in a placebo-controlled RCT aiming to determine whether BCG vaccination reduces the incidence and severity of COVID-19, we investigated the immunomodulatory effects of BCG on <i>in vitro</i> immune responses to SARS-CoV-2.<h4>Methods</h4>This study used peripheral blood taken from participants in the multicentre RCT and BCG vaccination to reduce","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T03:05:24.573Z","creation":"2024-11-20T22:38:02.24Z"},"accession":"S-EPMC9028103","cross_references":{"pubmed":["35573165"],"doi":["10.1002/cti2.1387"]}}