biostudies-literatureUnknown12(4)Mom RMénière's disease is a chronic illness characterized by intermittent episodes of vertigo associated with fluctuating sensorineural hearing loss, tinnitus and aural pressure. This pathology strongly correlates with a dilatation of the fluid compartment of the endolymph, so-called hydrops. Dexamethasone is one of the therapeutic approaches recommended when conventional antivertigo treatments have failed. Several mechanisms of actions have been hypothesized for the mode of action of dexamethasone, such as the anti-inflammatory effect or as a regulator of inner ear water homeostasis. However, none of them have been experimentally confirmed so far. Aquaporins (AQPs) are transmembrane water channels and are hence central in the regulation of transcellular water fluxes. In the present study, we iBiomolecules511https://www.ebi.ac.uk/biostudies/studies/S-EPMC9028334biostudies-literatureA Perspective for Meniere's Disease: In Silico Investigations of Dexamethasone as a Direct Modulator of AQP2.PMC9028334Robert-Paganin JAuguin DChabbert CRety SMom RMom TfalseA Perspective for Meniere's Disease: In Silico Investigations of Dexamethasone as a Direct Modulator of AQP2.Ménière's disease is a chronic illness characterized by intermittent episodes of vertigo associated with fluctuating sensorineural hearing loss, tinnitus and aural pressure. This pathology strongly correlates with a dilatation of the fluid compartment of the endolymph, so-called hydrops. Dexamethasone is one of the therapeutic approaches recommended when conventional antivertigo treatments have failed. Several mechanisms of actions have been hypothesized for the mode of action of dexamethasone, such as the anti-inflammatory effect or as a regulator of inner ear water homeostasis. However, none of them have been experimentally confirmed so far. Aquaporins (AQPs) are transmembrane water channels and are hence central in the regulation of transcellular water fluxes. In the present study, we i2022-01-01T00:00:00Z2022 Mar2026-04-08T18:20:46.93Z2024-10-17T20:02:52.776ZS-EPMC90283343545410010.3390/biom12040511