{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Weber P"],"funding":["Austrian Science Fund FWF"],"pagination":["15943-15951"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9029992"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(26)"],"pubmed_abstract":["A set of cyclopentanoid α-galactosidase ligands was prepared from a partially protected ω-eno-aldose <i>via</i> a reliable (2 + 3)-cycloaddition protocol with slightly modified conditions. The obtained <i>N</i>-benzylisoxazolidine ring was selectively opened and the configuration of the hydroxymethylgroup was inverted. Consecutive deprotection provided an aminocyclopentane, which was <i>N</i>-alkylated to furnish a set of potential α-galactosidase inhibitors. Their glycosidase inhibitory activities were screened with a panel of standard glycosidases of biological significance."],"journal":["RSC advances"],"pubmed_title":["New α-galactosidase-inhibiting aminohydroxycyclopentanes."],"pmcid":["PMC9029992"],"funding_grant_id":["P 30372"],"pubmed_authors":["Wolfsgruber A","Fischer R","Nasseri SA","Withers SG","Thonhofer M","Stutz AE","Weber P","Wrodnigg TM"],"additional_accession":[]},"is_claimable":false,"name":"New α-galactosidase-inhibiting aminohydroxycyclopentanes.","description":"A set of cyclopentanoid α-galactosidase ligands was prepared from a partially protected ω-eno-aldose <i>via</i> a reliable (2 + 3)-cycloaddition protocol with slightly modified conditions. The obtained <i>N</i>-benzylisoxazolidine ring was selectively opened and the configuration of the hydroxymethylgroup was inverted. Consecutive deprotection provided an aminocyclopentane, which was <i>N</i>-alkylated to furnish a set of potential α-galactosidase inhibitors. Their glycosidase inhibitory activities were screened with a panel of standard glycosidases of biological significance.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-05T11:05:16.717Z","creation":"2025-04-05T11:05:16.717Z"},"accession":"S-EPMC9029992","cross_references":{"pubmed":["35481199"],"doi":["10.1039/d1ra02507d"]}}