biostudies-literatureLiso APON AIM4358https://www.ebi.ac.uk/biostudies/studies/S-EPMC9030159biostudies-literatureUnknown23(8)Insulin-like growth factors binding protein-6 (IGFBP-6) is involved in a relevant number of cellular activities and represents an important factor in the immune response, particularly in human dendritic cells (DCs). Over the past several years, significant insights into the IGF-independent effects of IGFBP-6 were discovered, such as the induction of chemotaxis, capacity to increase oxidative burst and neutrophils degranulation, ability to induce metabolic changes in DCs, and, more recently, the regulation of the Sonic Hedgehog (SHH) signaling pathway during fibrosis. IGFBP-6 has been implicated in different human diseases, and it plays a rather controversial role in the biology of tumors. Notably, well established relationships between immunity, stroma activity, and fibrosis are prognosticInternational journal of molecular sciencesIGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis.PMC9030159PON AIM R&I 2014-2020-1879351-3Coda ARDVenuto STibullo DLiso AGiallongo CPalumbo GAfalseIGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis.Insulin-like growth factors binding protein-6 (IGFBP-6) is involved in a relevant number of cellular activities and represents an important factor in the immune response, particularly in human dendritic cells (DCs). Over the past several years, significant insights into the IGF-independent effects of IGFBP-6 were discovered, such as the induction of chemotaxis, capacity to increase oxidative burst and neutrophils degranulation, ability to induce metabolic changes in DCs, and, more recently, the regulation of the Sonic Hedgehog (SHH) signaling pathway during fibrosis. IGFBP-6 has been implicated in different human diseases, and it plays a rather controversial role in the biology of tumors. Notably, well established relationships between immunity, stroma activity, and fibrosis are prognostic2022-01-01T00:00:00Z2022 Apr2025-04-26T13:01:41.039Z2025-04-06T14:08:36.254ZS-EPMC90301593545717510.3390/ijms23084358