{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(4)"],"submitter":["Grespi F"],"pubmed_abstract":["Gliomas are heterogeneous neoplasms, classified into grade I to IV according to their malignancy and the presence of specific histological/molecular hallmarks. The higher grade of glioma is known as glioblastoma (GB). Although progress has been made in surgical and radiation treatments, its clinical outcome is still unfavorable. The invasive properties of GB cells and glioma aggressiveness are linked to the reshaping of the cytoskeleton. Recent works suggest that the different susceptibility of GB cells to antitumor immune response is also associated with the extent and function of mitochondria-ER contact sites (MERCs). The presence of MERCs alterations could also explain the mitochondrial defects observed in GB models, including abnormalities of energy metabolism and disruption of apoptot"],"journal":["Biomolecules"],"pagination":["567"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9030160"],"repository":["biostudies-literature"],"pubmed_title":["The Interplay of Microtubules with Mitochondria-ER Contact Sites (MERCs) in Glioblastoma."],"pmcid":["PMC9030160"],"pubmed_authors":["Cagnin S","De Mario A","Grespi F","Vianello C","Giacomello M"],"additional_accession":[]},"is_claimable":false,"name":"The Interplay of Microtubules with Mitochondria-ER Contact Sites (MERCs) in Glioblastoma.","description":"Gliomas are heterogeneous neoplasms, classified into grade I to IV according to their malignancy and the presence of specific histological/molecular hallmarks. The higher grade of glioma is known as glioblastoma (GB). Although progress has been made in surgical and radiation treatments, its clinical outcome is still unfavorable. The invasive properties of GB cells and glioma aggressiveness are linked to the reshaping of the cytoskeleton. Recent works suggest that the different susceptibility of GB cells to antitumor immune response is also associated with the extent and function of mitochondria-ER contact sites (MERCs). The presence of MERCs alterations could also explain the mitochondrial defects observed in GB models, including abnormalities of energy metabolism and disruption of apoptot","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-18T03:12:12.968Z","creation":"2025-04-04T10:01:47.758Z"},"accession":"S-EPMC9030160","cross_references":{"pubmed":["35454156"],"doi":["10.3390/biom12040567"]}}