{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(4)"],"submitter":["Versaci F"],"pubmed_abstract":["<h4>Background</h4>Aging is an independent risk factor for cardiovascular diseases. The autophagy process may play a role in delaying aging and improving cardiovascular function in aging. Data regarding autophagy in atrial fibrillation (AF) patients are lacking.<h4>Methods</h4>A post hoc analysis of the prospective ATHERO-AF cohort study, including 150 AF patients and 150 sex- and age-matched control subjects (CS), was performed. For the analysis, the population was divided into three age groups: &lt;50-60, 61-70, and &gt;70 years. Oxidative stress (Nox2 activity and hydrogen peroxide, H<sub>2</sub>O<sub>2</sub>), platelet activation (PA) by sP-selectin and CD40L, endothelial dysfunction (nitric oxide, NO), and autophagy parameters (P62 and ATG5 levels) were assessed.<h4>Results</h4>Nox2 a"],"journal":["Antioxidants (Basel, Switzerland)"],"pagination":["698"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9030744"],"repository":["biostudies-literature"],"pubmed_title":["Aging-Related Decline of Autophagy in Patients with Atrial Fibrillation-A Post Hoc Analysis of the ATHERO-AF Study."],"pmcid":["PMC9030744"],"pubmed_authors":["Versaci F","D'Amico A","Nocella C","Sciarretta S","Carnevale R","Cammisotto V","Spinosa G","D'Ambrosio L","Violi F","Pignatelli P","Schiavon S","Vecchio D","Schirone L","Chimenti I","Frati G","Bartimoccia S","Valenti V","Forte M","Pastori D"],"additional_accession":[]},"is_claimable":false,"name":"Aging-Related Decline of Autophagy in Patients with Atrial Fibrillation-A Post Hoc Analysis of the ATHERO-AF Study.","description":"<h4>Background</h4>Aging is an independent risk factor for cardiovascular diseases. The autophagy process may play a role in delaying aging and improving cardiovascular function in aging. Data regarding autophagy in atrial fibrillation (AF) patients are lacking.<h4>Methods</h4>A post hoc analysis of the prospective ATHERO-AF cohort study, including 150 AF patients and 150 sex- and age-matched control subjects (CS), was performed. For the analysis, the population was divided into three age groups: &lt;50-60, 61-70, and &gt;70 years. Oxidative stress (Nox2 activity and hydrogen peroxide, H<sub>2</sub>O<sub>2</sub>), platelet activation (PA) by sP-selectin and CD40L, endothelial dysfunction (nitric oxide, NO), and autophagy parameters (P62 and ATG5 levels) were assessed.<h4>Results</h4>Nox2 a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-22T10:58:07.652Z","creation":"2024-11-19T21:20:49.248Z"},"accession":"S-EPMC9030744","cross_references":{"pubmed":["35453383"],"doi":["10.3390/antiox11040698"]}}