biostudies-literatureUnknown11(4)Versaci F<h4>Background</h4>Aging is an independent risk factor for cardiovascular diseases. The autophagy process may play a role in delaying aging and improving cardiovascular function in aging. Data regarding autophagy in atrial fibrillation (AF) patients are lacking.<h4>Methods</h4>A post hoc analysis of the prospective ATHERO-AF cohort study, including 150 AF patients and 150 sex- and age-matched control subjects (CS), was performed. For the analysis, the population was divided into three age groups: &lt;50-60, 61-70, and &gt;70 years. Oxidative stress (Nox2 activity and hydrogen peroxide, H₂O₂), platelet activation (PA) by sP-selectin and CD40L, endothelial dysfunction (nitric oxide, NO), and autophagy parameters (P62 and ATG5 levels) were assessed.<h4>Results</h4>Nox2 aAntioxidants (Basel, Switzerland)698https://www.ebi.ac.uk/biostudies/studies/S-EPMC9030744biostudies-literatureAging-Related Decline of Autophagy in Patients with Atrial Fibrillation-A Post Hoc Analysis of the ATHERO-AF Study.PMC9030744Versaci FD'Amico ANocella CSciarretta SCarnevale RCammisotto VSpinosa GD'Ambrosio LVioli FPignatelli PSchiavon SVecchio DSchirone LChimenti IFrati GBartimoccia SValenti VForte MPastori DfalseAging-Related Decline of Autophagy in Patients with Atrial Fibrillation-A Post Hoc Analysis of the ATHERO-AF Study.<h4>Background</h4>Aging is an independent risk factor for cardiovascular diseases. The autophagy process may play a role in delaying aging and improving cardiovascular function in aging. Data regarding autophagy in atrial fibrillation (AF) patients are lacking.<h4>Methods</h4>A post hoc analysis of the prospective ATHERO-AF cohort study, including 150 AF patients and 150 sex- and age-matched control subjects (CS), was performed. For the analysis, the population was divided into three age groups: &lt;50-60, 61-70, and &gt;70 years. Oxidative stress (Nox2 activity and hydrogen peroxide, H₂O₂), platelet activation (PA) by sP-selectin and CD40L, endothelial dysfunction (nitric oxide, NO), and autophagy parameters (P62 and ATG5 levels) were assessed.<h4>Results</h4>Nox2 a2022-01-01T00:00:00Z2022 Apr2025-04-22T10:58:07.652Z2024-11-19T21:20:49.248ZS-EPMC90307443545338310.3390/antiox11040698